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ProteomicsDistinct (Phospho)proteomic Landscapes of PIK3CA Mutants Reveal Insulin-Mediated Reactivation of PI3K Pathway and Adaptive MAPK Signaling
Oncogenic mutations in p110α subunit of phosphatidylinositol-3-kinase (PI3K), primarily H1047R in the kinase domain and E545K in the helical domain, induce constitutive PI3K/AKT pathway activation, driving tumor progression. Isoform-specific inhibitors such as alpelisib have been developed, but thei...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD067648 | Pride
Proteomics  phosphoproteomics  pik3ca mutation 
TranscriptomicsAKT Isoform Specificity Downstream of PIK3CA Mutation Impacts Estradiol and PI3K Inhibitor Response in Breast Cancer Cells
Background: PIK3CA mutations are observed in >30% of breast cancers, which are more common in estrogen receptor (ERα)-positive breast cancer compared with ERα-negative breast cancer. AKT1, 2, and 3 isoforms, major isoforms downstream of PI3K, modulate ERα activity. It is unknown whether PIK3CA mu...
ORGANISM(S): Homo sapiens 
2016-08-10 | E-GEOD-60759 | biostudies-arrayexpress
GenomicsGene expression profiling of HUVEC-s expressing PIK3CA with H1047R point mutation
Gene expression profiling of HUVEC-s expressing PIK3CA with H1047R point mutation
PRJNA804236 | ENA
ProteomicsPhosphoproteomic analysis of breast epithelial cells with isogenic knockin of PIK3CA mutations
The PIK3CA gene is frequently mutated in human cancers. To study the signaling mechanisms responsible for cell growth and invasion phenotypes induced by mutant PIK3CA molecules, we carried out a SILAC-based quantitative phosphoproteomic analysis of MCF10A, a spontaneously immortalized normal mammary...
ORGANISM(S): Homo sapiens (Human) 
2015-07-28 | PXD000599 | Pride
Breast cancer Ls-ms/ms Pik3ca Phosphorylation Proteome Mutation 
TranscriptomicsKnock-in of PIK3CA-H1047R into MCF-10A
We have compared the proteome, transcriptome and metabolome of two isogenic cell lines: MCF-10A, derived from human breast epithelium, and the mutant MCF-10A-H1047R. These cell lines differ by a single amino acid substitution (H1047R) caused by single nucleotide change in one allele of the PIK3CA ge...
ORGANISM(S): Homo sapiens 
2015-01-19 | E-GEOD-63452 | biostudies-arrayexpress
GenomicsTranscriptome analysis of mouse tumors driven by PIK3CA mutation variants
Transcriptome analysis of mouse tumors driven by PIK3CA mutation variants
PRJNA508980 | ENA
TranscriptomicsTranscription profiling by array of human estrogen receptor alpha positive breast tumors with and without PIK3CA mutations.
PI3K/AKT pathway plays one of pivotal roles in breast cancer development and maintenance. PIK3CA, coding PIK3 catalytic subunit, is the oncogene which shows the high frequency of gain-of-function mutations leading to the PI3K/AKT pathway activation in breast cancer. In particular in the ERα-positive...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-22035 | biostudies-arrayexpress
TranscriptomicsSubtypes of HPV-positive head and neck cancers are associated with HPV characteristics, copy number variations, PIK3CA mutation, and pathway signatures. [RNA-Seq]
Purpose: There is substantial heterogeneity within the human papillomavirus (HPV) positive head and neck cancer (HNC) tumors that predispose them to different outcomes, however this subgroup is poorly characterized due to various historical reasons. Experimental Design: we perform unsupervised gene...
ORGANISM(S): Homo sapiens 
2016-05-13 | E-GEOD-74927 | biostudies-arrayexpress
UnknownIdentification and Characterization of a Novel Constitutional PIK3CA Mutation in a Child Lacking the Typical Segmental Overgrowth of "PIK3CA-Related Overgrowth Spectrum".
Not available
S-EPMC4752430 | biostudies-literature
GenomicsActivating PIK3CA mutation promotes overgrowth of adipose tissue via inhibiting lipophagy in macrodactyly
Activating PIK3CA mutation promotes overgrowth of adipose tissue via inhibiting lipophagy in macrodactyly
PRJNA1267137 | ENA
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