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MetabolomicsGut microbial release of ferulic acid from germinated quinoa alleviates obesity-associated cognitive impairment via activation of PINK1/Parkin-mediated mitophagy in the hippocampus

Background Obesity is a major risk factor for cognitive impairment and related neurodegenerative disorders. Whole grains are rich in polyphenols and dietary fiber, and their consumption has been associated with improvements in obesity and cognitive deficits. Gut microbial genes encode enzymes tha...

2026-03-30 | MTBLS14185 | MetaboLights
ProteomicsPutative PINK1/Parkin activators cause mitochondrial stress and lower the threshold for mitophagy
The PINK1/Parkin pathway is responsible for targeting damaged mitochondria for degradation via mitophagy. Because genetic evidence links impaired mitophagy to Parkinson’s disease, pharmacologic enhancement of mitophagy represents a promising disease-modifying strategy. Here, we characterize two phar...
ORGANISM(S): Homo sapiens (Human) 
2025-06-03 | PXD058150 | Pride
Mitochondria  mitophagy Autophagy  pink1/parkin pathway  mitochondrial stress  neurodegeneration  parkinson’s disease  integrated stress response (isr)  drug discovery  off-target toxicity. 
GenomicsA unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy
A unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy
PRJNA1268205 | ENA
UnknownThe PINK1/Parkin pathway regulates mitochondrial morphology.
Not available
S-EPMC2234197 | biostudies-literature
OtherA unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy
Damaged mitochondria can be cleared from the cell by mitophagy, using a pathway formed by the recessive Parkinson’s disease genes PINK1 and Parkin. Whether the pathway senses diverse forms of mitochondrial damage by a common mechanism, however, remains uncertain. Here, using a novel Parkin reporter ...
ORGANISM(S): Homo sapiens 
2025-08-06 | GSE298056 | GEO
UnknownPINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis.
Not available
S-EPMC6880866 | biostudies-literature
UnknownStructural basis for feedforward control in the PINK1/Parkin pathway.
Not available
S-EPMC9194792 | biostudies-literature
UnknownTemporal integration of mitochondrial stress signals by the PINK1:Parkin pathway.
Not available
S-EPMC6694515 | biostudies-literature
UnknownHexokinases link DJ-1 to the PINK1/parkin pathway.
Not available
S-EPMC5622528 | biostudies-literature
UnknownReactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin.
Not available
S-EPMC5633131 | biostudies-literature
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