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MetabolomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of met...
2021-07-30 | MTBLS533 | MetaboLights
MetabolomicsThe effects of PKM2 modulation and hypoxia on the metabolic landscape of Alzheimer patient-derived induced neurons
Not available
ORGANISM(S): Homo sapiens 
ST002214 | MetabolomicsWorkbench
TranscriptomicsSmall molecule activation of PKM in cancer cells induces serine auxotrophy
Proliferating tumor cells use aerobic glycolysis to support their high metabolic demands. Paradoxically, increased glycolysis is often accompanied by expression of the lower activity PKM isoform, effectively constraining lower glycolysis. Here, we report the discovery of novel PKM activators with ...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-GEOD-40191 | biostudies-arrayexpress
GenomicsEffect of deletion of PKM on gene expression in dental epithelium during tooth development
Effect of deletion of PKM on gene expression in dental epithelium during tooth development
PRJNA1398225 | ENA
TranscriptomicsSmall molecule activation of PKM in cancer cells induces serine auxotrophy
Proliferating tumor cells use aerobic glycolysis to support their high metabolic demands. Paradoxically, increased glycolysis is often accompanied by expression of the lower activity PKM isoform, effectively constraining lower glycolysis. Here, we report the discovery of novel PKM activators with a ...
ORGANISM(S): Homo sapiens 
2012-12-20 | GSE40191 | GEO
GenomicsPyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce translational stalling
Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce translational stalling
PRJNA837585 | ENA
TranscriptomicsSpinal Ependymoma Gene Expression Data
Purpose: Myxopapillary ependymoma (MPE) is a distinct histological variant of ependymoma arising commonly in the spinal cord. Despite an overall favorable prognosis, distant metastases, subarachnoid dissemination, and late recurrences have been reported. Currently the only effective treatment for M...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-66787 | biostudies-arrayexpress
UnknownPKM-ζ is not required for hippocampal synaptic plasticity, learning and memory.
Not available
S-EPMC3830948 | biostudies-literature
UnknownDiscovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers.
Not available
S-EPMC7835739 | biostudies-literature
TranscriptomicsEffect of deletion of PKM on gene expression in dental epithelium during tooth development
To elucidate the role of pyruvate kinase M (PKM) in tooth development, we conditionally deleted PKM in dental epithelium of mice. We then collected dental epithelium from control and knockout groups at postnatal day 0 to conduct gene expression profiling.
ORGANISM(S): Mus musculus 
2026-02-28 | GSE315538 | GEO
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