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TranscriptomicsIncrease in membrane cholesterol of neurons in culture recapitulates AlzheimerM-bM-^@M-^Ys disease early phenotypes.
Levels of membrane-associated cholesterol were shown to be increased in the brain of individuals with sporadic AlzheimerM-bM-^@M-^Ys disease (AD) and correlated with the severity of the disease. We previously found that heavy membrane cholesterol burden promotes amyloid precursor protein (APP) endoc...
ORGANISM(S): Rattus norvegicus 
2015-01-15 | E-GEOD-46221 | biostudies-arrayexpress
TranscriptomicsImpact of Elevated Plasma 5-HT on Global Gene Expression of Murine Megakaryocytes
The goal of this project was to understand the functional consequences of plasma biogenic amine serotonin (5-HT) elevation in megakaryocytes by measuring gene expression Total RNA was extracted from the megakaryocytes of mice treated with either 5-HT or saline and global gene expression was measured...
ORGANISM(S): Mus musculus 
2014-04-04 | E-GEOD-37273 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of control and ELL2-depleted MPC11 plasmacytoma cell lines
We report RNA-Seq data from MPC11 plasmacytoma cell lines transduced with either control hairpins (shGFP) or hairpins targeting the transcriptional elongation factor ELL2. ELL2 has been identified as regulating the alternative splicing and polyadenylation of immunoglobulin pre-mRNA, and is highly e...
ORGANISM(S): Mus musculus 
2012-09-07 | E-GEOD-40285 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of Tissue, Plasma and Urinary Extracellular Vesicles of Prostate Cancer patients
We performed RNA-Seq analysis of plasma and urinary EVs collected before and after radical prostatectomy, and matched tumor and normal prostate tissues of 10 patients with prostate cancer. To identify putative cancer-derived RNA biomarkers, we searched for RNAs that were overexpressed in tumor as co...
ORGANISM(S): Homo sapiens 
2022-11-16 | E-MTAB-11910 | biostudies-arrayexpress
ProteomicsComparison of pairwise venous and fingertip plasma using quantitative proteomics based on DIA
This project contains the proteome datasets generated from the fingertip and venous plasma samples of healthy volunteers
ORGANISM(S): Homo Sapiens 
2023-02-08 | PXD039952 |
ProteomicsPlasma membrane-associated proteins identified in Arabidopsis wild type, lbr2-2 and bak1-4 mutants treated with LPSs from Pseudomonas syringae and Xanthomonas campestris
We performed label-free LC-MS/MS profile of plasma membrane associated proteins from Arabidopsis thaliana wild type, lbr2-2 and bak1-4 mutants treated with two bacterial LPS chemotypes
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2023-05-23 | PXD034031 | JPOST Repository
TranscriptomicsAnalysis of human myeloma cell lines expressing beta 3 integrin
The aim of these experiments was designed to compare gene expression in human myeloma cell lines expressing beta 3 integrin vs counterpart cell lines that do not express beta 3 integrin. Keywords: Gene expression,cell lines, siRNA Phenotype characterization of both primary and cultured myeloma plas...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-15867 | biostudies-arrayexpress
UnknownInfluenza virus entry and infection require host cell N-linked glycoprotein.
Not available
S-EPMC535801 | biostudies-literature
TranscriptomicsGenome-wide array comparative genomic hybridization (aCGH) profiling of endothelial progenitor cells, and their comparison to tumor plasma cells, in multiple myeloma
In multiple myeloma (MM), endothelial progenitor cells (EPCs) regulate tumor angiogenesis and disease progression. EPCs from 16 newly diagnosed patients with advanced MM were examined for genomic instability by aCGH to assess chromosomal gains and losses. Data were compared to aCGH results from corr...
ORGANISM(S): Homo sapiens 
2011-04-02 | E-GEOD-28329 | biostudies-arrayexpress
TranscriptomicsTransport of influenza A virus neuraminidase to host cell surface and virus replication are regulated by ARHGAP21 and Cdc42
Influenza virus neuraminidase (NA), a type II transmembrane glycoprotein, is transported to the virus assembly site at the plasma membrane and is a major viral envelope component that plays a critical role in the release of progeny virions and in determination of host range restriction. Although sig...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-32878 | biostudies-arrayexpress
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