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GenomicsFaecal microbiota composition in wild-type and plectin-deficient mice
Faecal microbiota composition in wild-type and plectin-deficient mice
PRJNA561691 | ENA
GenomicsMulti-tissue epigenetic analysis of the osteoarthritis susceptibility locus mapping to the plectin gene PLEC
Multi-tissue epigenetic analysis of the osteoarthritis susceptibility locus mapping to the plectin gene PLEC
PRJNA601438 | ENA
TranscriptomicsMulti-tissue epigenetic analysis of the osteoarthritis susceptibility locus mapping to the plectin gene PLEC
We report an immortalised CRISPR-Cas9 mesenchymal stem cell line knockdown of Plectin, we initally noted that patients with osteoarthritis association single nucelotide polymorphism rs11780978 had a correlation between genotype at rs11780978 and allelic expression imbalance, with a reduced expressio...
ORGANISM(S): Homo sapiens 
2020-07-07 | GSE143725 | GEO
ProteomicsXilmass: a new approach towards the identification of cross-linked peptides
Chemical cross-linking coupled with mass spectrometry plays an important role in unravelling protein interactions, especially weak and transient interactions. Moreover, cross-linking complements several structure determination approaches such as cryo-EM. Although several computational approaches are...
ORGANISM(S): Homo sapiens (Human) 
2016-09-27 | PXD003880 | Pride
Calmodulin Cross-linking The actin-binding domain (abd) of plectin Dss Human 
ProteomicsPlectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis – in vitro phosphoproteomics
The most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence suggests that tissue mechanics plays a critical role in tumor onset and progression. Here we show that plec...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD060083 | Pride
Hepatocellular carcinoma  plectin  plecstatin-1 Target Metastasis 
ProteomicsPlectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis – in vivo profiling
The most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence suggests that tissue mechanics plays a critical role in tumor onset and progression. Here we show that plec...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-22 | PXD060054 | Pride
Hepatocellular carcinoma  plectin  plecstatin-1 Target Metastasis 
ProteomicsPlectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis – subcellular in vitro profiling
The most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence suggests that tissue mechanics plays a critical role in tumor onset and progression. Here we show that plec...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD060086 | Pride
Hepatocellular carcinoma  plectin  plecstatin-1 Target Metastasis 
UnknownPlectin contributes to mechanical properties of living cells.
Not available
S-EPMC2670656 | biostudies-literature
UnknownBinding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding.
Not available
S-EPMC2174221 | biostudies-literature
UnknownA compound heterozygous one amino-acid insertion/nonsense mutation in the plectin gene causes epidermolysis bullosa simplex with plectin deficiency.
Not available
S-EPMC1850321 | biostudies-literature
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