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ProteomicsAncestral mechanism of Calmodulin binding to Cds1 kinase inhibits catalytic activity
SDA chemical crosslinking mass spectrometry was used to investigate the interaction between the Cds1 kinase and Ca2+-Calmodulin from Schizosaccharomyces pombe. Upon binding of Ca2+-Calmodulin, Cds1 is allosterically inhibited.
ORGANISM(S): Schizosaccharomyces pombe 
2026-09-14 | PXD070930 | Pride
Schizosaccharomyces pombe Calmodulin Calcium Cell cycle Cds1 kinase 
ProteomicsHDX-MS Analysis of CHK2 Incubated with Calmodulin
To determine the conformational dynamics upon binding of calmodulin to serine/threonine kinase CHK2.
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PXD048473 | Pride
Chk2 Calmodulin Hdx-ms 
TranscriptomicsmicroRNA-1 negatively regulates expression of the hypertrophy-associated genes calmodulin and Mef2a
Calcium signaling is a central regulator of cardiomyocyte growth and function. Calmodulin is a critical mediator of calcium signals. Because the amount of calmodulin within cardiomyocytes is limiting, precise regulation of calmodulin expression may be an important for regulation of calcium signaling...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-13874 | biostudies-arrayexpress
ModelsStefan2008 - calmodulin allostery
Stefan2008 - calmodulin allostery An allosteric model for calmodulin activation, in which binding to calcium facilitates the transition between a low-affinity [tense (T)] and a high-affinity [relaxed (R)] state. This model is described in the article: An allosteric model o...
2024-09-02 | BIOMD0000000183 | BioModels
TranscriptomicsWhole genome transcription profile of antigen receptor activated B cells expressing wildtype or Calmodulin (CaM) - resistant E12
To elucidate the genome-wide role of Ca2+/ calmodulin inhibition of E2A in regulation of BCR activation, we performed DNA microarray analysis of activated splenic B cells expressing wildtype or CaM-resistant E12 mutant m8N47 with and without anti-IgM treatment for 3 hour.The expression of a remarkab...
ORGANISM(S): Mus musculus 
2012-07-10 | E-GEOD-35747 | biostudies-arrayexpress
TranscriptomicsCaMKII inhibition in smooth muscle cells controls Ang-II-induced gene transcription in the aorta
The Ca2+/calmodulin-dependent kinase II is expressed in smooth muscle and believed to mediate intracellular calcium handling and calcium-dependent gene transcription. CaMKII is activated by Angiotensin-II. The multifunctional calcium/calmodulin-dependent kinase II (CaMKII) is activated by Angiotensi...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-64613 | biostudies-arrayexpress
ModelsLai2014 - Hemiconcerted MWC model of intact calmodulin with two targets
Lai2014 - Hemiconcerted MWC model of intact calmodulin with two targets This model is described in the article: Modulation of calmodulin lobes by different targets: an allosteric model with hemiconcerted conformational transitions. Lai M, Brun D, Edelstein SJ, Le Novère N. ...
2024-09-02 | BIOMD0000000574 | BioModels
ModelsLi2019 - Neurogranin stimulates Ca/calmodulin-dependent kinase II by inhibiting Calcineurin
Calmodulin sits at the center of molecular mechanisms underlying learning and memory. Its complex, and sometimes opposite, influences via the binding to various proteins are yet to be fully understood. Calcium/calmodulin-dependent protein kinase II (CaMKII) and calcineurin (CaN) both bind open calmo...
2019-12-18 | MODEL1903010001 | BioModels
ProteomicsStructural analysis of the interaction between M-PMV matrix protein and human calmodulin – XL-MS dataset
Calmodulin serves as a regulator for various proteins, such as enzymes, kinases or phosphatases. It can also serve as Ca2+-dependent adaptor protein. Due to the previous evidence that retroviruses use host cell calmodulin for their proliferation, we focused on the description of functional and struc...
ORGANISM(S): Homo sapiens (Human) Mason-Pfizer monkey virus 
2025-12-29 | PXD067304 | Pride
Calmodulin Protein cross-linking Structural proteomics Mason-pfizer monkey protein 
ProteomicsStructural analysis of the interaction between M-PMV matrix protein and human calmodulin – HDX-MS dataset
Calmodulin serves as a regulator for various proteins, such as enzymes, kinases or phosphatases. It can also serve as Ca2+-dependent adaptor protein. Due to the previous evidence that retroviruses use host cell calmodulin for their proliferation, we focused on the description of functional and struc...
ORGANISM(S): Homo sapiens (Human) Mason-Pfizer monkey virus 
2025-12-29 | PXD067350 | Pride
Calmodulin Hydrogen deuterium exchange Structural proteomics Mason-pfizer monkey protein 
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