Dataset Information
HDX-MS Analysis of CHK2 Incubated with Calmodulin
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
John Burke
LAB HEAD: Dr. John E. Burke
PROVIDER: PXD048473 | Pride | 2025-10-15
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 10_17_23_HNHDX2_HK_MSMS.d.rar | Other | |||
| 11_21_23_HN7_HK_ND.d.rar | Other | |||
| 11_22_23_HN7_CC_30s-1.d.rar | Other | |||
| 11_22_23_HN7_HK_30s-1.d.rar | Other | |||
| 11_23_23_HN7_CC_300s-1.d.rar | Other |
Items per page: 1 - 5 of 39 |
Publications
Unconventional binding of Calmodulin to CHK2 kinase inhibits catalytic activity.
The Biochemical journal 20250923
Calmodulin (CaM) serves an essential role in eukaryotic cells as a Ca2+ sensor. Ca2+ binding leads to conformation changes in CaM that enable engagement of a repertoire of enzymes and the regulation of their catalytic activities. Classically, Ca2+-CaM binds to an inhibitory pseudosubstrate sequence C-terminal to the kinase domain in members of the Ca2+-CaM dependent protein kinase (CAMK) family, and relieves inhibition to promote catalytic activity. Here, we report an unexpected mechanism by whi ...[more]