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ProteomicsHDX-MS Analysis of CHK2 Incubated with Calmodulin
To determine the conformational dynamics upon binding of calmodulin to serine/threonine kinase CHK2.
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PXD048473 | Pride
Chk2 Calmodulin Hdx-ms 
ProteomicsJAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability
Checkpoint kinase 2 (CHK2) plays an important role in safeguarding the mitotic progression, specifically the spindle assembly, though the mechanism of regulation remains poorly understood. Here, we identified a novel mitotic phosphorylation site on CHK2 Tyr156, and its responsible kinase JAK2. Expre...
ORGANISM(S): Homo sapiens (Human) 
2024-10-16 | PXD056821 | Pride
Phosphorylation Chk2 Lc-ms/ms 
TranscriptomicsTranscription profiling of mouse Nbs1a??B/a??B Chk2-/- and Mre11ATLD1/ATLD1 Chk2-/- animals reveals Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
The Mre11 complex (Mre11, Rad50, and Nbs1) and Chk2 have been implicated in the DNA damage response, an inducible process required for the suppression of malignancy. The Mre11 complex is predominantly required for repair and checkpoint activation in S phase, while Chk2 governs apoptosis. We examin...
ORGANISM(S): Homo sapiens 
2008-06-20 | E-GEOD-11436 | biostudies-arrayexpress
ProteomicsThe Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing
Checkpoint kinase signaling in low dextrose growth conditions: SILAC phosphoproteome (IMAC-enriched peptides) - Light channel = dun1 deletion yeast grown in low dextrose minimal media. Heavy channel = rad53 deletion yeast grown in low dextrose minimal media.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-07-28 | PXD020272 | Pride
Budding yeast Phosphoproteome Low dextrose 
GenomicsCHK2 deficiency affects the engagement of DSBs repair pathways following DNA damage
CHK2 deficiency affects the engagement of DSBs repair pathways following DNA damage
PRJNA1297661 | ENA
TranscriptomicsChk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
The Mre11 complex (Mre11, Rad50, and Nbs1) and Chk2 have been implicated in the DNA damage response, an inducible process required for the suppression of malignancy. The Mre11 complex is predominantly required for repair and checkpoint activation in S phase, while Chk2 governs apoptosis. We examined...
ORGANISM(S): Mus musculus Homo sapiens 
2008-05-15 | GSE11436 | GEO
TranscriptomicsExpression data of ATM, ATR, CHK1, CHK2, and 53BP1 shRNA knockdown and control shRNA in MCF-10A cells
Homologous recombination-mediated DNA repair deficiency (HRD) predisposes to cancer development, but also provides therapeutic opportunities. Here, we identified an HRD gene signature that robustly predicted HRD status. Unexpectedly, concurrent loss of PTEN in BRCA1-deficient cells might extensively...
ORGANISM(S): Homo sapiens 
2014-01-24 | E-GEOD-54268 | biostudies-arrayexpress
TranscriptomicsCHK2 deficiency affects the engagement of DSBs repair pathways following DNA damage
Checkpoint kinase 2 (CHK2) participates in the DNA damage response (DDR) by regulating the cell cycle or inducing apoptosis, and its abnormal activity can lead to cancer development. CHK2 loss-of-function mutations correlate with the onset of many types of tumors and with therapy resistance. As the ...
ORGANISM(S): Homo sapiens 
2026-09-08 | GSE303774 | GEO
ProteomicsPhosphoproteomics reveals that cinobufotalin promotes intrahepatic cholangiocarcinoma cell apoptosis by activating the ATM/CHK2/p53 signaling pathway
In this study, we found that CB inhibited ICC cell proliferation and promoted cell apoptosis. By using phosphoproteomics, we found significant changes in the proteome and phosphorylome associated with DNA damage and apoptosis in response to CB treatment. Further investigations demonstrated that CB i...
ORGANISM(S): Homo Sapiens 
2022-06-20 | PXD034717 |
ProteomicsJAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability
This dataset consists of 1 raw MS file and associated peak list and result file, acquired on an Orbitrap Elite mass spectrometer operated in Data Dependent Acquisition mode. The files are associated with a manuscript submitted for publication. Publication title: "JAK2-CHK2 signaling safeguards the ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-31 | MSV000087138 | MassIVE
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