precision therapy

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Unknown (8228)
Genomics (526)
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Methylation profiling (7)
Models (5)
Genomic (4)

Organisms

Homo sapiens (348)
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Canis lupus (2)
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Organisms

Homo sapiens (203)
Mus musculus (42)
Rattus norvegicus (3)
Danio rerio (2)
Canis lupus (1)
Salmonella enterica subsp. enterica serovar Typhimurium (1)
Mus sp. (1)
Mus musculus domesticus (1)
Arabidopsis thaliana (1)

Repository

ENA (387)
geo (213)
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biostudies-arrayexpress (91)
pride (58)
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Tissue

Cell culture (12)
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Carcinoma (1)
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Persistent severe asthma (1)
Bacterial pneumonia (1)
Diffuse midline glioma (1)
Esophagus adenocarcinoma (1)
Diffuse large B-cell lymphoma (1)
Oral cavity cancer (1)
Idiopathic pulmonary fibrosis (1)
Severe COVID-19 (1)
Prostate adenocarcinoma (1)
Prostate cancer (1)
Multiple myeloma (1)
Lymphoma (1)
Cancer (1)
Neuroblastoma (1)

Technology Type

Mass Spectrometry (58)
Mass spectrometry (37)
Bottom-up proteomics (25)
Data-independent acquisition (20)
Shotgun proteomics (15)
Mass spectrometry assay (11)
Data-dependent acquisition (5)
SWATH MS (4)
NMR spectroscopy (3)
Gel-based experiment (3)
Affinity purification coupled with mass spectrometry proteomics (3)
Illumina HiSeq 2500, ILLUMINA (2)
NMR spectroscopy assay (2)
DiaPASEF (2)
Chemical cross-linking coupled with mass spectrometry proteomics (2)
HiSeq X Ten (ILLUMINA), HiSeq X Ten, ILLUMINA (1)
OXFORD_NANOPORE, MinION (1)
ABI_SOLID, Illumina HiSeq 2000, Illumina 450K, AB 5500xl Genetic Analyzer, AB 5500 Genetic Analyzer, ILLUMINA (1)
Illumina MiSeq, ILLUMINA (1)
ILLUMINA, NextSeq 500 (1)
HiSeq X Ten, ILLUMINA, Illumina HiSeq 2500 (1)
Illumina_450K (1)
Illumina MiSeq, Illumina Genome Analyzer IIx (1)
All-ion fragmentation (1)

Instrument Platform

Illumina NovaSeq 6000 (15)
Illumina HiSeq 2500 (6)
Illumina HiSeq 2000 (5)
NextSeq 500 (4)
Orbitrap Exploris 480 (4)
10x Genomics Chromium Controller (3)
NextSeq 2000 (3)
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Illumina HiSeq 4000 (2)
LTQ Orbitrap Velos (2)
DELL PRECISION T7500 (1)
High-performance computing workstation (1)
Protocol computer workstation running R statistical software (1)
Thermal cycler (PCR); Covaris ME220 focused ultrasonicator; magnetic separation rack; Agilent TapeStation system (D5000 and D1000 ScreenTape assays); Qubit fluorometer or equivalent; microcentrifuge. (1)
JANUS® G3 MDT automated liquid handling workstation (PerkinElmer); thermal cycler or incubator (42 °C); Zymo DNA Clean & Concentrator columns; AMPure XP magnetic bead purification system; magnetic separation rack. (1)
Multichannel pipettes or automated liquid handler; 384-well tissue culture plates; Class II biological safety cabinet; CO₂ incubator (37 °C, 5% CO₂). (1)
QIAseqTM miRNA Library Kit (1)
ExoEasy Maxi Kit. (1)
Beckman ultracentrifuge (1)
TruSeq RNA Sample Preparation protocol (1)
Illumina NovaSeq X (1)
None (1)
Illumina MiSeq (1)
NextSeq 550 (1)
Illumina HiSeq 3000 (1)
Illumina NextSeq 500 (1)
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LTQ Orbitrap Elite (1)
TripleTOF 6600 (1)

Publication Date

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2025 (89)
2024 (71)
2022 (38)
2023 (33)
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2014 (16)
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2019 (13)
2010 (12)
2018 (10)
2015 (9)
2016 (8)
2017 (6)
2013 (5)
2012 (5)
2011 (5)
2009 (2)
2008 (2)
2007 (2)

CHEBI ID

CHEBI:6650 (13)
CHEBI:18012 (13)
CHEBI:30769 (13)
CHEBI:25017 (12)
CHEBI:15428 (12)
CHEBI:28044 (12)
CHEBI:18186 (11)
CHEBI:17724 (11)
CHEBI:17568 (11)
CHEBI:17084 (11)
CHEBI:18300 (11)
CHEBI:16359 (11)
CHEBI:27897 (11)
CHEBI:33508 (10)
CHEBI:15611 (10)
CHEBI:25094 (10)
CHEBI:17234 (10)
CHEBI:28300 (10)
CHEBI:17533 (10)
CHEBI:16708 (10)
CHEBI:16530 (10)
CHEBI:15741 (10)
CHEBI:17268 (10)
CHEBI:40992 (10)
CHEBI:15891 (10)
CHEBI:16449 (10)
CHEBI:16704 (10)
CHEBI:30915 (10)
CHEBI:17596 (10)
CHEBI:6801 (4)

Metabolite Name

Tryptophan (8)
Phenylalanine (8)
Tyrosine (8)
Isoleucine (8)
Leucine (8)
Glycine (8)
N-acetylglucosaminylasparagine (7)
(R)-3-hydroxybutyrylcarnitine (7)
Trimethylamine N-oxide (7)
N-formylmethionine (7)
N-acetylarginine (7)
N-acetylalanine (7)
Gamma-glutamylglutamate (7)
Deoxycarnitine (7)
4-guanidinobutanoate (7)
Sphingosine (7)
N-acetylneuraminate (7)
2,6-dihydroxybenzoic acid (7)
Serine (7)
Lysine (7)
Kynurenine (7)
Cysteine (7)
Cystathionine (7)
Arginine (7)
Adenine (7)
Histidine (7)
Urea (7)
Mannose (7)
Threonine (7)
Glucose (7)

First Public Date

2026 (94)
2024 (78)
2025 (58)
2023 (44)
2022 (33)
2021 (18)
2019 (13)
2020 (12)
2014 (12)
2018 (9)
2015 (6)
2017 (5)
2013 (4)
2016 (1)

Modelling Approach

Ordinary differential equation model (5)
Physiologically based pharmacokinetic model (4)

Study status

Not yet recruiting (2)
Not provided (2)
Recruiting (2)
Withdrawn (1)
Completed (1)

Lab affiliation

GSK Chair in Chemical Biology, Imperial College London Satellite Group Leader, Francis Crick Institute Founder & SAB, Myricx Bio https://myricxbio.com/ Room 301B, Molecular Sciences Research Hub, White City Campus 82 Wood Lane, London W12 0BZ, UK Tel.: 020759 + Ext. 43752 or 45821 (group) http://www.imperial.ac.uk/tate-group/ (2)
Faculty of Medecine, University Paris Cité SFR Necker INSERM US24 160 rue de Vaugirard | 75015 Paris (1)
Cancer Signalling Research Group, School of Biomedical Science and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, AUSTRALIA. Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, AUSTRALIA. (1)
Clinical Proteomics Medizinisches Proteom-Center Ruhr-University Bochum and Department of Anesthesiology, Intensive Care Medicine and Pain Therapy University Hospital Knappschaftskrankenhaus Bochum (1)
Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University (1)
Department of Oncology-Pathology, Karolinska Institutet and Science for Life Laboratory (lab head) (1)
CDSS Bioanalytical Facility, Liverpool Shared Research Facilities, University of Liverpool (1)
Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore (1)
Dept for Biomedical Research, University of Bern; Inselspital and Bern Center for Precision Medicine (1)
ITC Life Sciences and Technology Center 3, 1st Main Road, 1st Phase, Peenya, Bangalore. 560058. India. (1)
Department of Chemistry, Imperial College London, Molecular Research Science Hub, 82 Wood Lane, London W12 0BZ, United Kingdom. The Francis Crick Institute, 1 Midland Road, London NW1 1AT, United Kingdom. (1)
Laboratory of Peroxisome Biology and Intracellular Communication, Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, 3000 Leuven, Belgium (1)
Department of Child Health and Child Health Research Institute, School of Medicine, University of Missouri, Columbia, MO, United States (1)
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pathology, Berlin, Germany. (1)
Institute of Organic Chemistry and Biochemistry Czech Academy of Sciences Flemingovo nám 542/2, 160 00, Prague, Czech Republic (1)
Department of Proteomics and Signal Transduction; Max-Planck Institute of Biochemistry; Martinsried, Bavaria, 82152; Germany (1)
Systems Pharmacology lab, Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Finland (1)
Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou 510060, P. R. China. (1)
Professor and Deputy Director, Center for Systems Biology and Molecular Medicine Yenepoya Research Centre, Yenepoya (Deemed to be University) Mangalore, India (1)
UNC LCCC, Pharmacology (1)
University of Bern, Department of BioMedical Research (DBMR), Lung Precision Medicine (LPM) Program (1)
CEITEC—Central European Institute of Technology, Masaryk University, Brno, Czech Republic (1)
1. Division of Radiation Health, 2. Department of Pharmaceutical Sciences, 3. Neurobiology & Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR (1)
Department of Tumor Biology, Institute for Cancer ResearchThe Norwegian Radium Hospital, Oslo University Hospital (1)
Laboratory of Cancer Metabolism, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology (1)
Medizinisches Proteom-Center, Ruhr University Bochum Clinic for Anesthesiology, Intensive Care and Pain Therapy, Knappschaft Clinics University Hospital Bochum (1)
Functional proteomis lab, Life Sciences Dept., University of Siena (1)
Department of Molecular Biology, Cristea Lab, Princeton University, Princeton, NJ, US (lab head) (1)
1School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, NSW, 2308, Australia 2 Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia (1)
Clinical Proteomics, Medizinisches Proteom-Center, Ruhr-University Bochum; Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital, Knappschaftskrankenhaus Bochum (1)

Keyword

Adiro 100 mg (1)
Adiro 300 mg (1)
Aspirin (1)

IsPrivate

False (5)

Submitter Keywords

TransQST (1)

Classification

bacteria (1)

Study type

Transcription profiling by array (34)
RNA-seq of coding RNA (25)
ChIP-seq (6)
RNA-seq of coding RNA from single cells (5)
Interventional (5)
Unknown experiment type (4)
Comparative genomic hybridization by array (3)
RNA-seq of total RNA (3)
Observational (3)
DNA-seq (2)
GRO-seq (1)
One-color microarray (1)
Animal - High-throughput sequencing (1)
Transcription profiling by tiling array (1)
MicroRNA profiling by high throughput sequencing (1)
Bisulfite-seq (1)
ATAC-seq (1)
Other (1)
Methylation profiling by array (1)

Release Date

2025 (1698)
2022 (1179)
2023 (1169)
2024 (1110)
2021 (893)
2020 (630)
2019 (388)
2026 (333)
2018 (318)
2017 (209)
2016 (156)
2015 (97)
2014 (61)
2012 (19)
2013 (17)
2010 (14)
2011 (9)
2009 (5)
2008 (5)
2007 (5)
2005 (2)
2006 (1)

Location

China (2)
Hong Kong (1)
Finland (1)
Spain (1)
United States (1)
Australia (1)

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Using a rhabdomyosarcoma patient-derived xenograft to examine precision medicine approaches and model acquired resistance.

Original patient tumor is directly implanted in mice xenografts. Tumor is propagated to multiple mice for conduct of 6 arm treatment trials and control. Therapies are selected based on T0 and F0 genomic profiles. ICE-T refractory tumor are implanted and additional 6 arm treatment trial and control c...

ORGANISM(S): Homo sapiens

2014-07-22 | E-GEOD-51130 | biostudies-arrayexpress

VA APOLLO Project - Research for Precision Oncology (RePOP)

The Research for Precision Oncology Program (RePOP) is a research activity that establishes a cohort of Veterans diagnosed with cancer and who have had genomic analyses performed on their tumor tissue as part of standard of care. All data relevant to a patient's cancer and cancer care will be...

phs001374 | dbGaP

Clinical-proteomic classification and precision treatment strategy of chordoma

ORGANISM(S): Homo Sapiens

PXD053631 |

Precision Phenomics to Personalized Drug Therapy (P3DT)

PRJNA595706 | ENA

Precision Phenomics to Personalized Drug Therapy (P3DT)

PRJNA595707 | ENA

Epigenomic characterization of patient-derived lung tumoroids using DNA methylation profiling

DNA methylation analysis of patient-derived lung tumoroids and matched healthy organoids demonstrates preservation of tumor-specific epigenomic identity during long-term culture. Tumoroids maintain the methylation landscape of their parental tumors, with samples from the same patient clustering toge...

ORGANISM(S): Homo sapiens

2025-12-29 | E-MTAB-16020 | biostudies-arrayexpress

PEDS-PLAN – Pediatric Precision Laboratory Advanced Neuroblastoma Therapy

PRJNA683101 | ENA

PEDS-PLAN – Pediatric Precision Laboratory Advanced Neuroblastoma Therapy

PRJNA683102 | ENA