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MetabolomicsA polyamine-centric blood-based metabolite panel predictive of poor response to CAR T-cell therapy in large B cell lymphoma

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory (r/r) large B-cell lymphoma (LBCL) results in durable response in only a subset of patients. MYC overexpression in LBCL tumors is associated with poor response to treatment. We tested whether a MYC-driven polyamin...

2022-10-31 | MTBLS5381 | MetaboLights
MetabolomicsQuantitative LC-MS study of compounds found predictive of COVID-19 severity and outcome

INTRODUCTION: Since the beginning of the SARS-CoV-2 pandemic in December 2019 multiple metabolomics studies have proposed predictive biomarkers of infection severity and outcome. Whilst some trends have emerged, the findings remain intangible and uninformative when it comes to n...

2024-04-23 | MTBLS7429 | MetaboLights
MetabolomicsSequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID

The post-acute sequelae of COVID-19 (PASC), also known as long COVID, is often associated with debilitating symptoms and adverse multisystem consequences. We obtain plasma samples from 117 individuals during and 6 mth following their acute phase of infection to comprehensively profile and as...

2024-02-23 | MTBLS7337 | MetaboLights
MetabolomicsA general non-self response as part of plant immunity
Plants, like other multicellular lifeforms, are colonized by microorganisms. How plants respond to their microbiota is currently not well understood. We used a phylogenetically diverse set of 39 endogenous bacterial strains from Arabidopsis thaliana leaves to assess host transcriptional and metaboli...
2021-09-13 | MTBLS2522 | MetaboLights
ProteomicsScreening protein predictive of response to tumor necrosis factor-α inhibitors treatment in rheumatoid arthritis by using iTRAQ technique and investigating its mechanism through signal pathway Screening protein predictive of response to tumor necrosis factor-α inhibitors treatment in rheumatoid arthritis by using iTRAQ technique and investigating its mechanism through signal pathway
Rheumatoid arthritis (RA) is a chronic and disabling disease. TNF-α inhibitors have demonstrated an outstanding performance in relieving joint inflammation and retarding bone erosion involved in RA. However, there is still about one-thirds of RA patients had a poor response to TNF α inhibitors. Curr...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD010400 | Pride
Rheumatoid arthritis  tumor necrosis factor α inhibitor  predictive of response  itraq  signal pathway 
MetabolomicsThe metabolic response of marine copepods to environmental warming and ocean acidification in the absence of food
Marine copepods are central to the productivity and biogeochemistry of marine ecosystems. Nevertheless, the direct and indirect effects of climate change on their metabolic functioning remain poorly understood. Here, we use metabolomics, the unbiased study of multiple low molecular weight organic me...
2015-10-13 | MTBLS91 | MetaboLights
ProteomicsEnhancing Concurrent Chemoradiation Outcome Prediction for Locally Advanced Cervical Cancer Patients Through Plasma Extracellular Vesicle Proteomics Analysis
Majority of the patients with cervical cancer present with locally advanced cervical cancer (LACC), which is primarily treated using concurrent chemoradiation (CCRT) and lacks reliable predictive biomarkers. Extracellular vesicles (EVs) could potentially define the dynamic biological response to CCR...
ORGANISM(S): Homo Sapiens (human) 
2024-09-30 | PXD050754 | JPOST Repository
ProteomicsScreening protein predictive of response to tumor necrosis factor-α inhibitors treatment in rheumatoid arthritis by using iTRAQ technique and investigating its mechanism through signal pathway
Rheumatoid arthritis (RA) is a chronic and disabling disease. TNF-α inhibitors have demonstrated an outstanding performance in relieving joint inflammation and retarding bone erosion involved in RA. However, there is still about one-thirds of RA patients had a poor response to TNF α inhibitors. Curr...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD010378 | Pride
Rheumatoid arthritis  tumor necrosis factor-α inhibitor  predictive of response  itraq  signal pathway 
TranscriptomicsDiscovery cohort for genomic predictor of response and survival following neoadjuvant taxane-anthracycline chemotherapy in breast cancer
PURPOSE: To develop a predictive test for response and survival following neoadjuvant taxane-anthracycline chemotherapy for HER2-negative invasive breast cancer. METHODS: We developed a microarray-based gene expression test from pre-treatment tumor biopsies (310 patients) to predict favorable outcom...
ORGANISM(S): Homo sapiens 
2011-05-11 | E-GEOD-25055 | biostudies-arrayexpress
MetabolomicsThe Impact of Ethnicity and Intra-Pancreatic Fat on the Postprandial Metabolome Response to Whey Protein in Overweight Asian Chinese and European Caucasian Women with Prediabetes
The 'Thin on the Outside Fat on the Inside' TOFI_Asia study found Asian Chinese to be more susceptible to Type 2 Diabetes (T2D) compared to European Caucasians matched for gender and body mass index (BMI). This was influenced by degree of visceral adipose deposition and ectopic fat accumulation in k...
2022-10-12 | MTBLS5568 | MetaboLights
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