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MetabolomicsPreterm birth is associated with xenobiotics and predicted by the vaginal metabolome
Spontaneous preterm birth (sPTB) is a leading cause of maternal and neonatal morbidity and mortality, yet its prevention and early risk stratification are limited. Previous investigations have suggested that vaginal microbes and metabolites may be implicated in sPTB. Here we performed untargeted met...
2022-11-21 | MTBLS702 | MetaboLights
MetabolomicsSurvival of the littlest: Navigating sepsis diagnosis beyond inflammation in preterm neonates
Background Sepsis diagnosis in preterm neonates is challenging due to symptom overlap with non-infectious inflammatory conditions, and slow, unreliable diagnostic practices. This study aims to identify metabolic biomarkers to elucidate sepsis pathophysiology, and enable timely, accurate diagnosis, w...
2025-07-07 | MTBLS10665 | MetaboLights
MetabolomicsGut Microbiota and Metabolomic Changes Across Preterm Stages: Potential Associations with Bronchopulmonary Dysplasia

The coordinated postnatal development of the gut microbiome and metabolome is essential for preterm infant health, yet its disruption is increasingly linked to adverse outcomes such as bronchopulmonary dysplasia (BPD). In this study, we performed an integrated multi-omics analysis of fecal sample...

2026-02-05 | MTBLS13364 | MetaboLights
ProteomicsData in support ofRapid proteome changes in plasma and cerebrospinal fluid following bacterial infection in preterm newborn pigs
Background: Neonatal infection and sepsis are common for preterm infants due to their immature immune system. Early diagnosis is important for effective treatment but few early markers of systemic and neuro-inflammatory responses in neonates are known. We hypothesized that systemic infection with Gr...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2020-05-26 | PXD016013 | Pride
Csf Proteomics Sepsis Pig 
GenomicsPreterm Birth Buccal Cell Epigenetic Biomarkers to Facilitate Preventative Medicine
Preterm Birth Buccal Cell Epigenetic Biomarkers to Facilitate Preventative Medicine
PRJNA799768 | ENA
ProteomicsPROTEOMIC PROFILING OF AMNIOS FOR PRETERM BIRTH BIOMARKER DISCOVERY
Spontaneous preterm birth (PTB) complicates about 12% of pregnancies worldwide, remaining the main cause of neonatal morbidity and mortality. A consistent number of PTB are caused by microbial-induced preterm labor, mediated by an inflammatory process, that threatens both maternal and newborn health...
ORGANISM(S): Homo sapiens (Human) 
2021-12-06 | PXD028343 | Pride
Proteomics Inflammation Amnios Mass spectrometry Preterm birth Biomarker 
Methylation profilingPreterm Birth Buccal Cell Epigenetic Biomarkers to Facilitate Preventative Medicine
Preterm birth is the major cause of newborn and infant mortality affecting nearly one in every ten live births. This study was designed to develop an epigenetic biomarker for susceptibility of preterm birth using buccal cells from the mother, father, and child (triads). MeDIP-seq was used to identif...
ORGANISM(S): Homo sapiens 
2022-03-09 | GSE194227 | GEO
ProteomicsData in support of plasma proteomics study forearly markers of antibiotics dependent necrotising enterocolitis in preterm pigs
Most hospitalized preterm infants receive antibiotics (AB) in the first days of life to treat or prevent systemic infections. Short-term, early AB treatment may also prevent against the microbiota-dependent serious gut disorder, necrotising enterocolitis (NEC). However, it remains a challenge to pre...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-09-08 | PXD015938 | Pride
Antibiotics Nec Plasma Pig 
ProteomicsData in support of Circulating neutrophil extracellular trap components including cell-free DNA are associated with neonatal sepsis and necrotizing enterocolitis in newborn, immature infants, pigs and mice
Preterm infants are highly susceptible to late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) but specific biomarkers for diagnosis and effective treatment are lacking. Neutrophil extracellular traps (NETs) are related to sepsis in adults but not investigated in infant conditions. This is th...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2018-03-05 | PXD004082 | Pride
Necrotizing enterocolitis Preterm neonates Sepsis Neutrophil extracellular traps 
UnknownEvaluation of heparinized syringes for measuring newborn metabolites in neonates with a central arterial line.
Not available
S-EPMC8671267 | biostudies-literature
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