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MetabolomicsSCUBE3 enhances post-myocardial infarction angiogenesis by promoting endothelial fatty acid metabolism

BACKGROUND: Myocardial infarction (MI), one of the leading causes of mortality worldwide, remains a clinical challenge due to limitations in current therapeutic strategies. The cardiac vascular network, as the fundamental architecture sustaining myocardial function, delivers oxygen and nutrients ...

2025-09-18 | MTBLS13005 | MetaboLights
MetabolomicsSCUBE3 enhances post-myocardial infarction angiogenesis by promoting endothelial fatty acid metabolism.

BACKGROUND: Myocardial infarction (MI), one of the leading causes of mortality worldwide, remains a clinical challenge due to limitations in current therapeutic strategies. The cardiac vascular network, as the fundamental architecture sustaining myocardial function, delivers oxygen and nutrients ...

2025-09-18 | MTBLS13004 | MetaboLights
TranscriptomicsA single cell transcriptome atlas of murine endothelial cells
The heterogeneity of endothelial cells (ECs), lining blood vessels, across tissues remains incompletely inventoried. We constructed an atlas of >32,000 single-EC transcriptomic data from 11 tissues of the model organism Mus musculus. We propose a new classification of EC phenotypes based on transcri...
ORGANISM(S): Mus musculus 
2020-02-13 | E-MTAB-8077 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of synectin knock-out mouse primary endothelial cells before and after FGF2 induction
Transcriptional regulatory effects of synectin deletion in murine primary endothelial cells both before and after FGF2 induction.
ORGANISM(S): Mus musculus 
2006-10-01 | E-MEXP-820 | biostudies-arrayexpress
TranscriptomicsGene expression in human umbilical cord endothelial cells following FoxP1 knockdown
To search for genes regulated by the transcription factor Forkhead box Protein P1 (FoxP1) in endothelial cells, we transfected human umbilical cord endothelial cells (HUVECs) with a combination of three siRNA oligonucleotides directed against human FoxP1 . Human umbilical vein endothelial cells (HU...
ORGANISM(S): Homo sapiens 
2013-11-12 | E-GEOD-32968 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of cultured corneal endothelial cells as a validation for their use in cell-replacement therapy
The corneal endothelium plays a primary role in maintaining corneal homeostasis and clarity, and must be surgically replaced with allogenic donor corneal endothelium in the event of visually significant dysfunction. However, a worldwide shortage of donor corneal tissue has led to a search for altern...
ORGANISM(S): Homo sapiens 
2015-09-04 | E-GEOD-65991 | biostudies-arrayexpress
TranscriptomicsMicrovascular endothelial heterogeneity
The goal of this study was to gain insight into the molecular heterogeneity of capillary endothelial cells derived from different organs by microarray profiling of freshly isolated cells and identify transcription factors that may determine the specific gene expression profile of endothelial cells f...
ORGANISM(S): Mus musculus 
2015-02-19 | E-GEOD-48209 | biostudies-arrayexpress
TranscriptomicsFunGenES: FunGenES_UKOE-5: Transcriptional profiling of CD31(+) cells isolated from murine embryonic stem cells
This experiment is part of the FunGenES project (FunGenES - Functional Genomics in Embryonic Stem Cells partially funded by the 6th Framework Programme of the European Union, http://www.fungenes.org). The experiment was conducted at University of Cologne, Cologne, Germany. Goal of the experiment is ...
ORGANISM(S): Mus musculus 
2011-02-25 | E-TABM-1125 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human ermal lymphatic endothelial cells (LEC) with those isolated from tumours of murine T241/VEGF-C/GFP metastatic fibrosarcoma reveals lymphatic endothelium of metastatic tumours has a distinct transcription profile.
Invasion of lymphatic vessels is a key step in the metastasis of primary tumour cells to draining lymph nodes. Recent evidence indicates that such metastasis can be facilitated by tumour lymphangiogenesis, although it remains unclear whether this is a consequence of increased lymphatic vessel number...
ORGANISM(S): Mus musculus 
2008-10-25 | E-GEOD-6255 | biostudies-arrayexpress
ProteomicsData in support of Synthesis and deposition of basement membrane proteins by primary brain capillary endothelial cells in a murine model of the blood-brain barrier
The aim of the present study was to analyze four different in vitro models of the murine BBB for expression and possible secretion of major basement membrane proteins from murine BCECs (mBCECs). The mBCECs and pericytes were isolated from brains of adult C57BL/6 mice, and glial cells (mainly astrocy...
ORGANISM(S): Mus musculus (Mouse) 
2016-08-03 | PXD003981 | Pride
Blood-brain barrier  primary murine capillary endothelial cells  basement membrane  in vitro models 
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