protein misfolding diseases

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Lab affiliation

The University of Manchester (3)
Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010. Australia (2)
Department of Neurobiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA (2)
1Department of Medicine, The University of Chicago (1)
1Department of Neurodegenerative Science, Van Andel Institute (1)
Associate Professor, New York University - Department of Biology, Center for Genomics & Systems Biology (1)
Ben-Gurion University (1)
Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, United Kingdom (1)
DZNE Munich, Neuroproteomics, Feodor-Lynen Str. 17, 81377 Munich, Germany (1)
Department of Biology, Stanford University, Stanford, USA (1)
Department of Biologyy, University of Rochester, NY, USA University of Rochester Mass Spectrometry Resource Laboratory, NY, USA (1)
Department of Biomedical Sciences, University of Padova, Italy CNR-Neuroscience Institute, Italy Padova Neuroscience center, University of Padova, Italy (1)
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA (1)
Department of Immunopathology, PGIMER, Chandigarh (1)
Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA (1)
Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Germany (1)
Department of Veterinary Medicine and Animal Sciences (DIVAS), University of Milano (1)
Departments of Chemistry and Biological Sciences, Vanderbilt University (1)
Dept. of Molecular Cell Biology, Institute of Biochemistry of the Romanian Academy (IBRA) (1)
Dept. of Molecular and Cellular Biology, University of Geneva (1)
Division of Neurobiology The Roslin Institute Royal (Dick) School of Veterinary Studies College of Medicine and Veterinary Medicine University of Edinburgh Easter Bush Midlothian EH25 9RG SCOTLAND, UK t: 44 (0)131 651 9119 e: T.M.Wishart@Roslin.ed.ac.uk website: http://www.roslin.ed.ac.uk/tom-wishart http://www.euanmacdonaldcentre.com/research.html (1)
Institute of Microbiology,The Czech Academy of Sciences (1)
MIRCen, CNRS UMR 9199, Fontenay-aux-Roses, France (1)
McGill University, department of physiology, Canada (1)
Neurotoxin Research Group, School of Life Sciences, The University of Technology Sydney, Ultimo, NSW 2007, Australia; kenneth.rodgers@uts.edu.au (K.J.R.) (1)
Proteomics Lab. SaBio research group. Instituto de Investigación en Recursos Cinegéticos, IREC (CSIC-UCLM-JCCM) (1)
The Uinversity of Manchester (1)
University of Geneva, Faculty of Medicine, 1211 Geneva, Switzerland (1)
University of Wisconsin-Madison (1)
Vanderbilt University (1)

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SAR by kinetics for drug discovery in protein misfolding diseases.

Not available

S-EPMC6187117 | biostudies-literature

Redox control of the cAMP/PKA pathway during protein misfolding stress

Protein aggregation is the abnormal association of misfolded proteins into larger, often insoluble structures that can be toxic during ageing and in protein aggregation-associated diseases. This RNA-seq study in Saccharomyces cerevisiae investigated the role of Tsa1, which is a member of the highly ...

ORGANISM(S): Saccharomyces cerevisiae

2021-04-19 | E-MTAB-9355 | biostudies-arrayexpress

Nanobodies as therapies for loss-of-function misfolding diseases

Misfolding loss-of-function diseases are a huge burden for people and states. Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder caused by mutations in the alanine:glyoxylate aminotransferase 1 (AGT) enzyme. The underlying molecular mechanisms causing PH1 are associated with protein misfo...

ORGANISM(S): Homo sapiens (Human)

2026-01-06 | PXD060227 | Pride

Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy

PRJNA854161 | ENA

Probing the origin of prion protein misfolding via reconstruction of ancestral proteins.

Not available

S-EPMC9667828 | biostudies-literature

Expression data for inbred mouse brains

Prion diseases are fatal neurodegenerative disorders that include bovine spongiform encephalopathy (BSE) and scrapie in animals and Creutzfeldt-Jakob disease (CJD) in humans. They are characterized by long incubation periods, variation in which is determined by many factors including genetic backgro...

ORGANISM(S): Mus musculus

2012-09-04 | E-GEOD-38205 | biostudies-arrayexpress

Treating Protein Misfolding Diseases: Therapeutic Successes Against Systemic Amyloidoses.

Not available

S-EPMC7366848 | biostudies-literature

Redox control of the cAMP/PKA pathway during protein misfolding stress

PRJEB39415 | ENA

Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy

Mitophagy is essential to maintain mitochondrial function and prevent diseases. It activates upon mitochondria depolarization, which causes PINK1 stabilization on the mitochondrial outer membrane. Strikingly, a number of conditions, including mitochondrial protein misfolding, can induce mitophagy wi...

ORGANISM(S): Homo sapiens

2022-08-04 | GSE207212 | GEO

Prion protein misfolding.

Not available

S-EPMC3330701 | biostudies-literature

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