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MetabolomicsAqueous Artemisia argyi extract mitigates acute lung injury in association with coordinated alterations in gut microbiota, metabolic homeostasis, and pulmonary inflammatory gene expression
Background: Artemisia argyi is a traditional medicinal herb with established anti-inflammatory and immunomodulatory properties. Its aqueous extract (AEAA), enriched in water-soluble bioactive constituents, exhibits favorable safety and bioavailability; however, its potential protective effects again...
2026-03-27 | MTBLS14160 | MetaboLights
MetabolomicsAqueous Artemisia argyi extract mitigates acute lung injury in association with coordinated alterations in gut microbiota, metabolic homeostasis, and pulmonary inflammatory gene expression
his study investigated the metabolic alterations in colonic contents associated with aqueous extract of Artemisia argyi (AEAA) intervention in a lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model. Male C57BL/6 mice were randomly divided into control, LPS, and AEAA treatment groups ...
2026-03-27 | MTBLS14155 | MetaboLights
GenomicsDNA methylation alterations of driver genes in blood of high-altitude pulmonary edema ( RRBS)
DNA methylation alterations of driver genes in blood of high-altitude pulmonary edema ( RRBS)
PRJNA1124547 | ENA
TranscriptomicsGene expression profiling under exposure to high altitude hypoxic environment
Understanding molecular mechanism associated with high altitude exposure during acclimatization/adaptation/maladaptation. Data reveals specific components of the complex molecular circuitry underlying high altitude pulmonary edema. Individualized outcome prediction were constructed through expressio...
ORGANISM(S): Homo sapiens 
2013-12-18 | E-GEOD-52209 | biostudies-arrayexpress
GenomicsWhole transcriptomic landscape and regulatory network of High-Altitude Pulmonary Edema
Whole transcriptomic landscape and regulatory network of High-Altitude Pulmonary Edema
PRJNA1083989 | ENA
TranscriptomicsA Sphingosine 1-Phosphate 1 Receptor Agonist Modulates Brain Death-Induced Neurogenic Pulmonary Injury
Lung transplantation remains the only viable therapy for patients with end-stage lung disease; however, full utilization of this treatment strategy is severely compromised by the lack of donor lung availability. For example, the vast majority of donor lungs available for transplantation are obtained...
ORGANISM(S): Rattus norvegicus 
2010-07-30 | E-GEOD-22531 | biostudies-arrayexpress
Methylation profilingDNA methylation alterations of driver genes in blood of high-altitude pulmonary edema ( RRBS)
Epigenetics may play an important role in the occurrence and development of high-altitude pulmonary edema. To investigate the DNA methylation driving genes associated with high-altitude pulmonary edema, we also performed reduced representation bisulfite sequencing (RRBS) for blood identify differenc...
ORGANISM(S): Homo sapiens 
2025-06-30 | GSE269977 | GEO
TranscriptomicsExpression Data from Allogeneic Human Mesenchymal Stem Cells and Primary Cultures of Human Alveolar Epithelial Type II Cells
Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is a severe syndrome affecting more than 200,000 patients annually in the U.S. New studies are needed to understand the biological and clinical mechanisms that impair alveolar epithelial function. Also, innovative therapies are ...
ORGANISM(S): Homo sapiens 
2015-07-08 | E-GEOD-68610 | biostudies-arrayexpress
ProteomicsProteomic analysis of lung tissues in an oleic acid (OA)-induced acute lung injury model rats
Data analyzed proteins extracted from lung tissue samples from OA-induced acute lung injury model rats. Samples were collected at 0 (pretreatment), 3, 6, 24, 48, 96 h after OA administration. Whole tissue extracts were prepared from three individuals and analyzed using the DIA-MS method.
ORGANISM(S): Cellular Organisms 
2025-03-14 | PXD057386 | JPOST Repository
GenomicsGenome-wide DNA methylation analysis of driver genes in blood of high-altitude pulmonary edema
Genome-wide DNA methylation analysis of driver genes in blood of high-altitude pulmonary edema
PRJNA1117844 | ENA
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