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MetabolomicsSelective galactose culture condition reveals distinct metabolic signatures in pyruvate dehydrogenase and complex I deficient human skin fibroblasts

INTRODUCTION: A decline in mitochondrial function represents a key factor of a large number of inborn errors of metabolism, which lead to an extremely heterogeneous group of disorders.

OBJECTIVES: To gain insight into the biochemical consequences of mitocho...

2021-10-06 | MTBLS761 | MetaboLights
TranscriptomicsAnalysis of gene expression in Pseudonocardia dioxanivorans strain CB1190 during growth with dioxane, glycolate or pyruvate
Analysis of gene expression in Pseudonocardia dioxanivorans strain CB1190 during growth with dioxane, glycolate or pyruvate. Three treatments, based on carbon source used for growth: pyruvate, dioxane and glycolate. Triplicate microarrays (biological replicates) were prepared for each treatment. Pyr...
ORGANISM(S): Pseudonocardia dioxanivorans CB1190 
2012-02-21 | E-GEOD-33197 | biostudies-arrayexpress
TranscriptomicsCis- and trans-Regulation of Pneumococcal spxB
Pyruvate oxidase encoded by spxB is a major virulence factor in the human respiratory pathogen Streptococcus pneumoniae. During aerobic growth, SpxB synthesizes large amounts of H2O2 and acetyl phosphate, which can serve as a phosphoryl group donor to response regulators and be converted to ATP. Spx...
ORGANISM(S): Streptococcus pneumoniae 
2010-05-26 | E-GEOD-7109 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Burkittas lymphoma cell line, P493-6 to identify hypoxia responsive genes
Activation of glycolytic genes by HIF-1 is considered critical for metabolic adaptation to hypoxia. We found that HIF-1 also actively suppresses glucose metabolism through the tricarboxylic acid cycle (TCA) by directly trans-activating the gene encoding pyruvate dehydrogenase kinase 1 (PDK1). PDK1...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-4086 | biostudies-arrayexpress
TranscriptomicsEngineering acetyl-CoA supply: Functional expression of a bacterial pyruvate-dehydrogenase complex in the cytosol of Saccharomyces cerevisiae
The energetic (ATP) cost of biochemical pathways critically determines the maximum yield of metabolites of vital or commercial relevance. Cytosolic acetyl-CoA is a key precursor for biosynthesis in eukaryotes and for many industrially relevant product pathways that have been introduced into Saccharo...
ORGANISM(S): Saccharomyces cerevisiae 
2014-11-04 | E-GEOD-59814 | biostudies-arrayexpress
TranscriptomicsSpecific growth rate dependent transcriptome profiling of Escherichia coli K12 MG1655 in accelerostat cultures
Specific growth rate dependent gene expression changes of Escherichia coli K12 MG1655 were determined by microarray and real time PCR analyses. The bacteria were cultivated on glucose limited minimal medium using the accelerostat method (A-stat), where starting from steady state conditions in a chem...
ORGANISM(S): Escherichia coli 
2010-05-22 | E-GEOD-18183 | biostudies-arrayexpress
UnknownPyruvate oxidase is a determinant of Avery's rough morphology.
Not available
S-EPMC532437 | biostudies-literature
UnknownConcerted action of lactate oxidase and pyruvate oxidase in aerobic growth of Streptococcus pneumoniae: role of lactate as an energy source.
Not available
S-EPMC2395018 | biostudies-literature
GenomicsIntracellular metabolic gradients dictate dependence on exogenous pyruvate
Intracellular metabolic gradients dictate dependence on exogenous pyruvate
PRJNA1217024 | ENA
UnknownCharacterization and functional analysis of the poxB gene, which encodes pyruvate oxidase in Lactobacillus plantarum.
Not available
S-EPMC419957 | biostudies-literature
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