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GenomicsG-Quadruplex structures are stable and detectable in human genomic DNA.
The G-quadruplex is an alternative DNA structural motif that is considered to be functionally important in the mammalian genome. Herein, we address the hypothesis that G-quadruplex structures can exist within double-stranded genomic DNA using a G-quadruplex-specific probe. An engineered antibody is ...
ORGANISM(S): Homo sapiens 
2013-05-08 | E-GEOD-45241 | biostudies-arrayexpress
GenomicsSystematic identification of G-quadruplex sensitive lethality by genome-wide genetic screening
A375 and HT1080 cells are treated with G-quadruplex ligands PDS or PhenDC3 following genome-wide shRNA knockdown. This enables the identification of genes that when silenced, specifically compromises cell growth in the presence of the ligand. First, a pilot screen was performed to determine a ligand...
ORGANISM(S): Homo sapiens 
2019-06-22 | E-MTAB-6367 | biostudies-arrayexpress
GenomicsIdentification of G-quadruplex clusters by high-throughput sequencing of whole genome amplified products with G-quadruplex ligand
Identification of G-quadruplex clusters by high-throughput sequencing of whole genome amplified products with G-quadruplex ligand
PRJNA1273212 | ENA
ProteomicsModulation of the ATM / autophagy pathway tips the balance between senescence and apoptosis in response to a quadruplex ligand
G-quadruplex ligands (G4L) exert their anti-proliferative effect through telomere-dependent and -independent mechanisms, but the inter-relationship between autophagy, cell growth arrest and cell death induced by these ligands remains largely unexplored. 20A is a 2,4,6-triarylpyridine derivative that...
ORGANISM(S): Homo sapiens (Human) 
2019-02-19 | PXD009430 | Pride
G4  quadruplex ligand  autophagy  senescence  apoptosis  triarylpyridine  antiproliferative agents  label-free quantitative proteome analysis. 
UnknownPhenQE8, a Novel Ligand of the Human Telomeric Quadruplex.
Not available
S-EPMC7828518 | biostudies-literature
ProteomicsDegradation of G-Quadruplex Binding Proteins in Chromatin Using G4-Ligand-Based PROTACs
Targeted protein degradation can intervene with the function of disease-related proteins, but most current approaches rely on direct ligand engagement of a protein target, limiting their applicability to proteins that are difficult to bind selectively. We present a conceptually unique approach to de...
ORGANISM(S): Homo sapiens (Human) 
2026-01-27 | PXD073248 | Pride
G‑quadruplex  g4l‑protacs  chromatin  targeted protein degradation 
UnknownMechanistic insight into ligand binding to G-quadruplex DNA.
Not available
S-EPMC4027208 | biostudies-literature
UnknownPreferential binding of a G-quadruplex ligand to human chromosome ends.
Not available
S-EPMC1181860 | biostudies-literature
GenomicsG-quadruplex DNA as a target for pathogenic bacteria: efficacy of an extended naphthalene diimide ligand and mode of action
G-quadruplex DNA as a target for pathogenic bacteria: efficacy of an extended naphthalene diimide ligand and mode of action
PRJNA741414 | ENA
UnknownThe Herpes Simplex Virus-1 genome contains multiple clusters of repeated G-quadruplex: Implications for the antiviral activity of a G-quadruplex ligand.
Not available
S-EPMC7113899 | biostudies-literature
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