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ProteomicsProteomic Analysis of Rap1A GTPase Signaling-Deficient C57BL/6 Mouse Pancreas and Functional Studies Identify an Essential Role of Rap1A in Pancreas Physiology
The Ras-related Rap1A GTPase is implicated in pancreas β-cell insulin secretion, and is stimulated by the cAMP sensor Epac2, a guanine exchange factor and activator of Rap1 GTPase. In this study we examined the differential proteomic profiles by nanoLC-ESI-MS/MS of pancreata from C57BL/6 Rap1A-defic...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD052896 | Pride
Oral glucose tolerance test  insulin tolerance test Glucose-stimulated insulin secretion Pancreas  intracellular signaling  rap1a-gtpase  gene knockout  differential expression  nanolc-esims/ms  ero1lβ expression 
TranscriptomicsRap1a GTPase mVSM Knockout vs. Rescue Expression
This SuperSeries is composed of the following subset Series: GSE24749: Rap1a GTPase mVSM Knockout vs. Rescue miRNA Expression GSE25702: Rap1a GTPase mVSM Knockout vs. Rescue mRNA Expression Refer to individual Series
ORGANISM(S): Mus musculus 
2011-04-13 | E-GEOD-25703 | biostudies-arrayexpress
UnknownProteomic Analysis of Rap1A GTPase Signaling-Deficient C57BL/6 Mouse Pancreas and Functional Studies Identify an Essential Role of Rap1A in Pancreas Physiology.
Not available
S-EPMC11312117 | biostudies-literature
Genomics
Rap1a GTPase mVSM Knockout vs. Rescue Expression
PRJNA134115 | ENA
TranscriptomicsRap1a GTPase mVSM Knockout vs. Rescue Expression
This SuperSeries is composed of the SubSeries listed below.
ORGANISM(S): Mus musculus 
2011-04-13 | GSE25703 | GEO
GenomicsMus musculus
Rap1a GTPase mVSM Knockout vs. Rescue miRNA Expression
PRJNA142715 | ENA
GenomicsMus musculus
Rap1a GTPase mVSM Knockout vs. Rescue mRNA Expression
PRJNA142441 | ENA
TranscriptomicsRap1a GTPase mVSM Knockout vs. Rescue mRNA Expression
Transcriptional profiling of mouse tail artery explanted microvascular smooth muscle (mVSM) cells comparing Rap1a -/- mVSM cells transduced with vector backbone (control) with Rap1a -/- mVSM cells transduced with a Rap1 CA 'rescue' plasmid. The experiment will compare mRNA expression in Rap1A -/- mV...
ORGANISM(S): Mus musculus 
2011-04-13 | GSE25702 | GEO
GenomicsRap1a GTPase mVSM Knockout vs. Rescue miRNA Expression
miRNA profiling of mouse tail artery explanted microvascular smooth muscle (mVSM) cells comparing Rap1a -/- mVSM cells trasduced with vector backbone (control) with Rap1a -/- mVSM cells transduced with a Rap1 CA 'rescue' plasmid. The experiment will compare miRNA expression in Rap1A -/- mVSMs and 'r...
ORGANISM(S): Mus musculus 
2011-04-13 | GSE24749 | GEO
TranscriptomicsRap1a GTPase mVSM Knockout vs. Rescue mRNA Expression
Transcriptional profiling of mouse tail artery explanted microvascular smooth muscle (mVSM) cells comparing Rap1a -/- mVSM cells transduced with vector backbone (control) with Rap1a -/- mVSM cells transduced with a Rap1 CA 'rescue' plasmid. The experiment will compare mRNA expression in Rap1A -/- mV...
ORGANISM(S): Mus musculus 
2010-11-10 | E-GEOD-25190 | biostudies-arrayexpress
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