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TranscriptomicsRapamycin effect on gene expression: dependence on c-Myc
This experiment utilized rat fibroblasts that are wild-type for c-Myc (TGR-1 cells) and null for c-Myc (HO15.19 cells). Both were treated treated with rapamycin for 24 hr (comparison group, vehicle control). Cells were studied under conditions that supported proliferation. Rapamycin (50nM or DMSO ...
ORGANISM(S): Rattus norvegicus 
2010-10-25 | E-GEOD-18845 | biostudies-arrayexpress
TranscriptomicsLate life rapamycin treatment reverses age-related heart dysfunction
We report the mRNA profile of aged mice (24 months old) fed either a control diet or a diet containing Rapamycin (14 ppm) for 3 months. After drug treatement, the hearts of the mice were removed and total mRNA was removed from the tissue. Analysis revealed that there were 700 significantly different...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-48043 | biostudies-arrayexpress
TranscriptomicsGene expression data from rapamycin resistant and sensitive cell lines
The mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation. Inhibitors of mTOR are being evaluated as anti-tumor agents. Given the emerging role of microRNAs (miRNAs) in tumorgenesis we hypothesized that miRNAs could play important roles in the response of tumors to mTOR i...
ORGANISM(S): Mus musculus 
2013-02-08 | E-GEOD-19885 | biostudies-arrayexpress
TranscriptomicsMicroRNAs mediate rapamycin resistance in a myogenic tumor cell line
The mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation. Inhibitors of mTOR are being evaluated as anti-tumor agents. Given the emerging role of microRNAs (miRNAs) in tumorgenesis we hypothesized that miRNAs could play important roles in the response of tumors to mTOR i...
ORGANISM(S): Mus musculus 
2013-02-08 | E-GEOD-19916 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human rapamycin treated of MDA-MB-468 breast cancer cell line and MDA-MB-468 xenografts
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase involved in multiple intracellular signaling pathways promoting tumor growth. mTOR is aberrantly activated in a significant portion of breast cancers and is a promising target for treatment. Rapamycin and its analogues are in clinical...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-18571 | biostudies-arrayexpress
TranscriptomicsTLR-mediated type I IFN induction in pDCs requires the rapamycin-sensitive PI3K-mTOR-p70S6K pathway
Robust type I interferon (IFN-alpha/beta) production in plasmacytoid dendritic cells (pDCs) is critical for anti-viral immunity. Here we demonstrated a role for the mammalian target of rapamycin (mTOR) pathway in regulating interferon production by pDCs. Inhibition of mTOR or the ‘downstream’ mediat...
ORGANISM(S): Mus musculus 
2008-12-01 | E-GEOD-12218 | biostudies-arrayexpress
TranscriptomicsRapamycin extends life span, but has limited effects on aging in mice
Rapamycin extends life span in mice, but it remains unclear if this compound also delays mammalian aging. Here, we present results from a comprehensive large-scale assessment of a wide rage of structural and functional aging phenotypes in mice. Rapamycin extended life span but showed few effects on ...
ORGANISM(S): Mus musculus 
2013-07-29 | E-GEOD-41018 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast wild type and ggc1-delta strains after treatment with rapmycin
This experiment was a 4-part timeseries (or, 2x2x4 factorial design) designed to provide additional biological insight into the role of ggc1 in the rapamycin response of Saccharomyces cerevisiae. Treated and untreated cultures were compared at 0, 1, 2, and 4 hours of growth, in both WT and ggc1-del...
ORGANISM(S): Saccharomyces cerevisiae 
2010-01-07 | E-TABM-638 | biostudies-arrayexpress
TranscriptomicsExpression data from rapamycin treatment and/or p73 knock-down in Rh30 cells
p73 is a p53 family transcription factor that plays critical roles during development and tumor suppression. We analyzed p73 activity using a combination of ChIP-on-Chip and gene expression profiling, both at baseline and after treatment with the mTOR inhibitor rapamycin. We generated an mTOR-p73 g...
ORGANISM(S): Homo sapiens 
2011-01-05 | E-GEOD-15703 | biostudies-arrayexpress
TranscriptomicsCharacterization of T-rapamycin cells by gene expression profiling
Gene expression profiling of CD4+ T cells cultured in vitro in presence of IL-2, IL-4, Rapamycin for 12 days Sources tested: Day 0 CD4+ T cells (6 samples), Day 6 T-rapamycin cells (6 samples), Day 12 T-rapamycin cells (6 samples) 3 time points were compared: day 0 (cells before start the culture), ...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-GEOD-34911 | biostudies-arrayexpress
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