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Transcriptomics28d Rat Inhalation Study
We have performed a 28 days rat inhalation study according to the OECD TG 412 by exposing rats for 28 days to filtered air (sham), or to a low, medium, or high concentration of mainstream (MS) cigarette smoke (CS) from the Reference cigarette 3R4F in addition to MS CS from a prototypic modified risk...
ORGANISM(S): Rattus norvegicus 
2014-05-30 | E-MTAB-1842 | biostudies-arrayexpress
TranscriptomicsToxicity of the main electronic cigarette components, propylene glycol, glycerin and nicotine in Sprague Dawley rats in a 90-day OECD inhalation study complemented with molecular endpoints (Lung)
The main constituents of electronic cigarette liquids are nicotine, propylene glycol (PG), and vegetable glycerin (VG), together with distilled water and flavors. To assess the toxicity of PG/VG mixtures with and without nicotine as basic components of liquids used in e-cigarettes, a 90-day rat inha...
ORGANISM(S): Rattus norvegicus 
2017-11-03 | E-MTAB-5545 | biostudies-arrayexpress
TranscriptomicsToxicity of Toxicity of the main electronic cigarette components, propylene glycol, glycerin and nicotine in Sprague Dawley rats in a 90-day OECD inhalation study complemented with molecular endpoints (Liver)
The main constituents of electronic cigarette liquids are nicotine, propylene glycol (PG), and vegetable glycerin (VG), together with distilled water and flavors. To assess the toxicity of PG/VG mixtures with and without nicotine as basic components of liquids used in e-cigarettes, a 90-day rat inha...
ORGANISM(S): Rattus norvegicus 
2017-11-03 | E-MTAB-5544 | biostudies-arrayexpress
ProteomicsA proteomics investigation of cigarette smoke exposed Wistar rats revealed improved anti-inflammatory effects of the cysteamine nanoemulsions delivered via inhalation
Cigarette smoking is the major cause of chronic inflammatory diseases such as Chronic Obstructive Pulmonary Disease (COPD). It is paramount to develop pharmacological interventions and delivery strategies against the cigarette smoke (CS) associated oxidative stress in COPD. This study in Wistar rats...
ORGANISM(S): Rattus Norvegicus 
PXD033559 | panorama
ProteomicsSystems toxicological assessment of the mentholated Tobacco Heating System 2.2 product revealed reduced cellular and molecular exposure effects compared to cigarette smoke [quantitative proteomics of rat nasal epithelium]
Aiming to reduce smoking-related health risks, potential reduced risk products (pRRPs) are being developed. The Tobacco Heating System (THS) 2.2 is a recently developed pRRP, which utilizes the heat-not-burn principle. In this study, systems toxicology approaches were engaged to assess the respirato...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-12-13 | PXD003591 | Pride
Reduced risk tobacco product  systems toxicology  rat inhalation study  itraq 
ProteomicsToxicity of the main electronic cigarette components, propylene glycol, glycerin and nicotine in Sprague Dawley rats in a 90-day OECD inhalation study complemented with molecular endpoints [LUNG DATA]
The main constituents of electronic cigarette liquids are nicotine, propylene glycol (PG), and vegetable glycerin (VG), together with distilled water and flavors. To assess the toxicity of PG/VG mixtures with and without nicotine as basic components of liquids used in e-cigarettes, a 90-day rat inha...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-09-11 | PXD005959 | Pride
Rat Electronic cigarette Lung 
ProteomicsToxicity of the main electronic cigarette components, propylene glycol, glycerin and nicotine in Sprague Dawley rats in a 90-day OECD inhalation study complemented with molecular endpoints [RNE DATA]
The main constituents of electronic cigarette liquids are nicotine, propylene glycol (PG), and vegetable glycerin (VG), together with distilled water and flavors. To assess the toxicity of PG/VG mixtures with and without nicotine as basic components of liquids used in e-cigarettes, a 90-day rat inha...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-09-11 | PXD006894 | Pride
Respiratory nasal epithelium Rat Itraq Toxicology 
TranscriptomicsToxicity of the main electronic cigarette components, propylene glycol, glycerin and nicotine in Sprague Dawley rats in a 90-day OECD inhalation study complemented with molecular endpoints (RNE)
While the toxicity of the main constituents of electronic cigarette (ECIG) liquids, nicotine, propylene glycol (PG), and vegetable glycerin (VG), has been assessed individually in separate studies, limited data on the inhalation toxicity of them is available when in mixtures. In this 90-day subchron...
ORGANISM(S): Rattus norvegicus 
2017-11-03 | E-MTAB-5910 | biostudies-arrayexpress
TranscriptomicsGene expression microarray analysis of rat nasal tissue with time and dose following formaldehyde inhalation
Formaldehyde (FA), an endogenous cellular aldehyde, is a rat nasal carcinogen. In this study, concentration- and exposure-duration transitions in FA mode of action (MOA) were examined with pharmacokinetic (PK) modeling for tissue formaldehyde acetal (FAcetal) and glutathione (GSH) and with histopath...
ORGANISM(S): Rattus norvegicus 
2010-07-28 | E-GEOD-23179 | biostudies-arrayexpress
TranscriptomicsEvaluation of the Tobacco Heating System 2.2 (THS2.2). Part 5: microRNA expression from a 90-day rat inhalation study indicates that exposure to THS 2.2 aerosol causes reduced effects on lung tissue compared with cigarette smoke
Modified-risk tobacco products (MRTP) are designed to reduce the individual risk of tobacco-related disease as well as population harm compared to smoking cigarettes. Experimental proof of their benefit needs to be provided at multiple levels in research fields. Here, we examined microRNA (miRNA) le...
ORGANISM(S): Rattus norvegicus 
2016-11-30 | E-MTAB-5296 | biostudies-arrayexpress
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