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MetabolomicsMulti-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke
Cigarette smoke (CS) causes adverse health effects and leads to the development of respiratory disease (chronic obstructive pulmonary disease), cardiovascular disease, and cancer. To reduce the risk of smokers developing smoking-related diseases, Philip Morris International is developing modified ri...
2020-04-25 | MTBLS158 | MetaboLights
MetabolomicsSystems toxicology of a tire-wear pollutant: Multi-omics evidence for bioenergetic reprogramming in freshwater clams

The increasing release of tire-derived transformation products into aquatic ecosystems has raised significant environmental concerns, particularly regarding 6PPD-quinone (6PPDQ), a highly toxic compound formed from a widely used tire antioxidant. Despite growing attention, its chronic effects and...

2026-03-26 | MTBLS14142 | MetaboLights
MetabolomicsThe mechanism of vascular injury caused by polystyrene microplastics: A molecular toxicology study involving ferroptosis and metabolomics

Background: Polystyrene microplastics (PS-MPs) are degradation products of plastics that are prevalent in the environment. Recent studies have established a significant correlation between exposure to PS-MPs and the incidence of cardiovascular diseases (CVD). Objective: This study aims to investi...

2026-08-16 | MTBLS14514 | MetaboLights
TranscriptomicsThirteen-week Nose-only Inhalation Exposures of Propylene Glycol Aerosols in Sprague Dawley Rats with a Lung Systems Toxicology Analysis.
Propylene glycol (PG) is a common carrier in e-vapor formulations and its properties have been extensively studied. In this 13-week subchronic nose-only inhalation study, Sprague Dawley rats were exposed to filtered air (sham control group), propylene glycol/water (PG/W; 90:10) or a propylene glycol...
ORGANISM(S): Rattus norvegicus 
2021-09-07 | E-MTAB-10006 | biostudies-arrayexpress
UnknownCollaboration, competition and publication in toxicology: views of British Toxicology Society members.
Not available
S-EPMC6610305 | biostudies-literature
TranscriptomicsSystems toxicology assessment of CHTP1.2 [RNE Data]
Modified risk tobacco products (MRTPs) have the potential to reduce smoking-related health risks. The Carbon Heated Tobacco Product 1.2 (CHTP1.2) is a potential MRTP that uses a pressed carbon heat source to generate an aerosol by heating tobacco. This study reports the results from the systems toxi...
ORGANISM(S): Rattus norvegicus 
2018-04-10 | E-MTAB-6320 | biostudies-arrayexpress
TranscriptomicsSystems toxicology assessment of CHTP1.2 [Liver Data]
Modified risk tobacco products (MRTPs) have the potential to reduce smoking-related health risks. The Carbon Heated Tobacco Product 1.2 (CHTP1.2) is a potential MRTP that uses a pressed carbon heat source to generate an aerosol by heating tobacco. This study reports the results from the systems toxi...
ORGANISM(S): Rattus norvegicus 
2018-04-10 | E-MTAB-6317 | biostudies-arrayexpress
TranscriptomicsSystems toxicology assessment of CHTP1.2 [Lung Data]
Modified risk tobacco products (MRTPs) have the potential to reduce smoking-related health risks. The Carbon Heated Tobacco Product 1.2 (CHTP1.2) is a potential MRTP that uses a pressed carbon heat source to generate an aerosol by heating tobacco. This study reports the results from the systems toxi...
ORGANISM(S): Rattus norvegicus 
2018-04-10 | E-MTAB-6319 | biostudies-arrayexpress
TranscriptomicsAn application of a systems toxicology approach using a human organotypic small airway cultures for a comparative assessment between a candidate modified-risk tobacco product aerosol and cigarette smoke.
Along the trachea-bronchial tree, including the small airway region, cigarette smoke exposure induces inflammation, which can exacerbate the development of chronic obstructive pulmonary disease (COPD). The small airway region is known as the primary location of airway blockage in COPD and asthma. Th...
ORGANISM(S): Homo sapiens 
2017-10-26 | E-MTAB-6004 | biostudies-arrayexpress
TranscriptomicsSystems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells
The development of reduced-risk products is aimed at providing adult smokers, who are unable to quit, with alternatives to cigarettes that present less risk of harm and smoking-related disease. The use of flavors in the development of these reduced-risk products fulfils an important role in product ...
ORGANISM(S): Homo sapiens 
2019-11-01 | E-MTAB-7748 | biostudies-arrayexpress
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