rat model of t2dm

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Repository

biostudies-arrayexpress (24)
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pride (2)
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Tissue

Liver (1)
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Disease

Type 2 diabetes mellitus (1)

Technology Type

Mass spectrometry assay (2)
Mass Spectrometry (2)
Mass spectrometry (1)
Data-dependent acquisition (1)
Shotgun proteomics (1)

Instrument Platform

Flow Injection Analysis MS - Positive (FIA-MS (Positive)) (1)
Liquid Chromatography MS - positive - reverse-phase (1)
Liquid Chromatography MS - negative - reverse-phase (1)
Liquid Chromatography MS - positive - reverse phase (1)
Liquid Chromatography MS - negative - reverse phase (1)

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CHEBI ID

CHEBI:72736 (2)
CHEBI:64561 (2)
CHEBI:28867 (2)
CHEBI:72737 (2)
CHEBI:67075 (1)
CHEBI:137629 (1)
CHEBI:66974 (1)
CHEBI:137615 (1)
CHEBI:131427 (1)
CHEBI:137605 (1)
CHEBI:137604 (1)
CHEBI:66844 (1)
CHEBI:137597 (1)
CHEBI:74471 (1)
CHEBI:137557 (1)
CHEBI:137555 (1)
CHEBI:72538 (1)
CHEBI:132059 (1)
CHEBI:85759 (1)
CHEBI:137573 (1)
CHEBI:137649 (1)
CHEBI:137642 (1)
CHEBI:137589 (1)
CHEBI:137588 (1)
CHEBI:137587 (1)
CHEBI:85760 (1)
CHEBI:133629 (1)
CHEBI:72505 (1)
CHEBI:134460 (1)
CHEBI:72426 (1)

Metabolite Name

1,4-Methylimidazoleacetic acid (2)
PERICIAZINE (2)
Succinylmonocholine (2)
Ricinoleic Acid methyl ester (2)
N-(3-Aminopropyl)morpholine (2)
6E,8E,12E,14E-Hexadecatetraen-10-ynoic acid (2)
3,4-Dimethylstyrene (2)
Linoleoyl Ethanolamide (2)
Trolamine (2)
2-Indanone (2)
1-Linoleoylglycerophosphocholine (2)
N-heptanoyl-homoserine lactone (2)
Butoctamide hydrogen succinate (2)
Soyasaponin III (2)
Malvidin (2)
Palmitoleamide (2)
Pregnan-20-one, 17-(acetyloxy)-3-hydroxy-6-methyl-, (3b,5b,6a)- (2)
Lyso-PAF C-16 (2)
Glyceryl 5-hydroxydecanoate (2)
3-Hydroxydodecanedioic acid (2)
2'-Apo-beta-carotenal (2)
5-Aminopentanamide (2)
2-Pyridylacetic acid (2)
3,7-Dimethyl-8,11-dioxo-2E,6E,9E-dodecatrienal (2)
9,12,15-Octadecatrien-1-ol (2)
3-ketosphinganine (2)
Palmitic amide (2)
LysoPC(20:3(5Z,8Z,11Z)) (2)
4-Methyl-5-thiazoleethanol (2)
Uracil (2)

First Public Date

2026 (4)
2017 (3)
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2023 (2)
2014 (2)
2025 (1)
2022 (1)
2019 (1)
2013 (1)

Study type

Transcription profiling by array (19)
RNA-seq of coding RNA (2)
Comparative genomic hybridization by array (1)
ChIP-seq (1)
Methylation profiling by array (1)

Release Date

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2016 (9)
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2019 (9)
2017 (8)
2014 (7)
2018 (6)
2011 (5)
2010 (5)
2015 (4)
2012 (3)
2009 (3)
2026 (2)
2008 (1)
2007 (1)

Lab affiliation

Center for Innovative Engineering Technology in Traditional Chinese Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, China (1)
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital 300384 (1)

Tags

xref:PubMed:41770102 (2)
xref:PubMed:33329383 (1)
xref:PubMed:21901280 (1)
xref:PubMed:20194508 (1)
xref:PubMed:20454453 (1)

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Retinal proteomic study of high-fat diet-induced T2DM model: exploring the interventional targets of nonproliferative diabetic retinopathy

Objective: This study aims to establish a T2DM rat model consistent with the natural history of the disease, and apply TMT proteomics technology to analyze the retina to reveal the pathogenic mechanism of NPDR and search for new targets for NPDR intervention. Methods: Six-week-old SD male rats were ...

ORGANISM(S): Rattus norvegicus (Rat)

2025-05-07 | PXD056236 | Pride

Expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes

This SuperSeries is composed of the following subset Series: GSE17058: MiRNA expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes GSE17059: Gene expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes Refer to individual Series

ORGANISM(S): Rattus norvegicus

2010-05-16 | E-GEOD-17060 | biostudies-arrayexpress

Array CGH between GK and Wistar Rats for Detecting Copy Number Variations

The Goto-Kakizak (GK) rat, a nonobese animal model of Type 2 diabetes (T2D), were developed by repeated inbreeding of glucose-intolerent individuals selected from Wistar rats. During their development, GK rats suffer from reduced beta-cell mass and insulin resistance spontaneously (T2D phenotype), w...

ORGANISM(S): Rattus norvegicus

2010-12-31 | E-GEOD-21387 | biostudies-arrayexpress

MiRNA expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes

MicroRNAs (miRNAs) are non-coding RNA molecules involved in post-transcriptional control of gene expression of a wide number of genes, including those involved in glucose homeostasis. Type 2 diabetes (T2D) is characterized by hyperglycaemia and defects in insulin secretion and action at target tissu...

ORGANISM(S): Rattus norvegicus

2010-05-16 | E-GEOD-17058 | biostudies-arrayexpress

Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model.

Not available

S-EPMC4935135 | biostudies-literature

Genome-wide DNA methylation in normal and IUGR pancreatic islets

Intrauterine growth restriction (IUGR) increases susceptibility to age-related diseases including type 2 diabetes (T2DM), and is associated with permanent and progressive changes in gene expression and epigenetic regulation. We studied cytosine methylation throughout the genome in pancreatic islets...

ORGANISM(S): Rattus norvegicus

2010-06-24 | E-GEOD-16839 | biostudies-arrayexpress

Hepatic transcriptomic analyses revealing the molecular pathogenesis of T2DM associated NAFLD in the ZDF rats

PRJNA482127 | ENA

Hepatic transcriptomic analyses revealing the molecular pathogenesis of T2DM associated NAFLD in the ZDF rats

The ZDF rat, with spontaneous homozygous mutation of the leptin receptor gene (fa/fa), is one of the widely used animal model for studying the human type 2 diabetes mellitus (T2DM). Male ZDF rats have the symptoms of obesity and insulin resistance at a young age, accompanying with impaired islet fun...

ORGANISM(S): Rattus norvegicus

2019-05-01 | GSE117447 | GEO

Transcription profiling of rat adipose tissue

Male 130 day old rat adipose tissue from control and obese rats

ORGANISM(S): Rattus norvegicus

2008-06-11 | E-GEOD-1813 | biostudies-arrayexpress

Liver mitochondria-associated ER membrane proteomics for studying the effects of ZiBuPiYin recipe on Zucker diabetic fatty rats after chronic psychological stress

Type 2 diabetes mellitus (T2DM) is a complex metabolic disease with multiple etiologies, involving both genetic and environmental factors. With changes associated with modern life, increasing attention has been paid to chronic psychological stressors such as work stress. Chronic psychological stress...

ORGANISM(S): Rattus norvegicus (Rat)

2022-10-25 | PXD029226 | Pride

Type 2 diabetes mellitus Chronic psychological stress Zibupiyin recipe Proteomics Mitochondria-associated er membrane

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