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ProteomicsUSP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress
Tumor growth requires elevated ribosome biogenesis. Targeting ribosomes is an important strategy for cancer therapy. The ribosome inhibitor, homoharringtonine (HHT), is used for the clinical treatment of leukemia, yet it is ineffective for the treatment of solid tumors, the reasons for which remain ...
ORGANISM(S): Homo sapiens (Human) 
2023-09-26 | PXD045622 | Pride
Usp36  snail1  ribosome biogenesis  ribotoxic stress 
GenomicsNon-enzymatic RNA Glycation Links Metabolic Stress to Ribotoxic Stress Response and β-Cell Dysfunction
Non-enzymatic RNA Glycation Links Metabolic Stress to Ribotoxic Stress Response and β-Cell Dysfunction
PRJNA1419170 | ENA
GenomicsStalled ribosomes are signals for metabolic regulation by the ribotoxic stress response
Stalled ribosomes are signals for metabolic regulation by the ribotoxic stress response
PRJNA844063 | ENA
ProteomicsThe ribotoxic stress response drives UV-mediated cell death.
Supporting raw MS data for paper (doi: 10.1016/j.cell.2024.05.018) by Sinha N.K. et al, titled "The ribotoxic stress response drives UV-mediated cell death". Index of MS files and labels Table S1 - HaCaT Timecourse. 1-1 - Proteome (AO3604-3627 | Unimod:35; 2016; 4 | 126 -UT_01; 127n - UT_02; 12...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-07-25 | MSV000092521 | MassIVE
UnknownJNK activation induced by ribotoxic stress is initiated from 80S monosomes but not polysomes.
Not available
S-EPMC6726213 | biostudies-literature
UnknownA Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response.
Not available
S-EPMC5037485 | biostudies-literature
GenomicsInitiation of a ZAKa-dependent Ribotoxic Stress Response by the Innate Immunity Endoribonuclease RNase L
Initiation of a ZAKa-dependent Ribotoxic Stress Response by the Innate Immunity Endoribonuclease RNase L
PRJNA1066218 | ENA
GenomicsPoly-GR impairs translation elongation and increases ribotoxic stress response in C9ORF72-ALS/FTD
Poly-GR impairs translation elongation and increases ribotoxic stress response in C9ORF72-ALS/FTD
PRJNA957700 | ENA
UnknownInitiation of a ZAKα-dependent Ribotoxic Stress Response by the Innate Immunity Endoribonuclease RNase L.
Not available
S-EPMC10592832 | biostudies-literature
UnknownUSP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress.
Not available
S-EPMC10575996 | biostudies-literature
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