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ProteomicsThe Ubiquitin-Specific Protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing
The RNA exosome is an essential 3’ to 5’ processing exoribonuclease complex that mediates degradation, processing, and quality control of virtually all eukaryotic RNAs. The nucleolar RNA exosome, consisting of a 9-subunit core and a distributive 3ʹ to 5ʹ exonuclease EXOSC10, plays a critical role in...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD031592 | Pride
Human Deubiquitination Sumoylation Usp36 Ribosome biogenesis Rna exosome 
ProteomicsThe Ubiquitin-Specific Protease USP36 Promotes Small Nucleolar Ribonucleoprotein Group SUMOylation and is Essential for Ribosome Biogenesis
SUMOylation plays a crucial role in regulating diverse cellular processes including ribosome biogenesis. Proteomic analyses and experimental evidence showed that a number of nucleolar proteins involved in ribosome biogenesis are modified by SUMO. However, how these proteins are SUMOylated is less un...
ORGANISM(S): Homo sapiens (Human) 
2021-03-29 | PXD022987 | Pride
Spectral count Deubiquitinating enzyme Sumoylation Co-ip Nucleolus Homo sapiens Usp36 Ltq velos Ribosome biogenesis Sumo 
ProteomicsUSP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress
Tumor growth requires elevated ribosome biogenesis. Targeting ribosomes is an important strategy for cancer therapy. The ribosome inhibitor, homoharringtonine (HHT), is used for the clinical treatment of leukemia, yet it is ineffective for the treatment of solid tumors, the reasons for which remain ...
ORGANISM(S): Homo sapiens (Human) 
2023-09-26 | PXD045622 | Pride
Usp36  snail1  ribosome biogenesis  ribotoxic stress 
GenomicsSuper-enhancer-driven USP36 promotes glycolytic reprogramming and neuroblastoma progression by stabilizing DHX33
Super-enhancer-driven USP36 promotes glycolytic reprogramming and neuroblastoma progression by stabilizing DHX33
PRJNA1523870 | ENA
GenomicsSuper-enhancer-driven USP36 promotes glycolytic reprogramming and neuroblastoma progression by stabilizing DHX33 [RNAseq_shDHX33]
Super-enhancer-driven USP36 promotes glycolytic reprogramming and neuroblastoma progression by stabilizing DHX33 [RNAseq_shDHX33]
PRJNA1522772 | ENA
TranscriptomicsSuper-enhancer-driven USP36 promotes glycolytic reprogramming and neuroblastoma progression by stabilizing DHX33
Neuroblastoma (NB) is the most common extracranial solid tumor in children and is characterized by pronounced glycolytic metabolism and a poor clinical prognosis. However, its core pathogenic mechanisms and effective therapeutic targets remain incompletely understood. This study identifies ubiquitin...
ORGANISM(S): Homo sapiens 
2026-09-09 | GSE346164 | GEO
GenomicsThe function of USP36 in the ER positive Breast Cancer
The function of USP36 in the ER positive Breast Cancer
PRJNA1092965 | ENA
TranscriptomicsSuper-enhancer-driven USP36 promotes glycolytic reprogramming and neuroblastoma progression by stabilizing DHX33 [RNAseq_shDHX33]
Neuroblastoma (NB) is the most common extracranial solid tumor in children and is characterized by pronounced glycolytic metabolism and a poor clinical prognosis. However, its core pathogenic mechanisms and effective therapeutic targets remain incompletely understood. This study identifies ubiquitin...
ORGANISM(S): Homo sapiens 
2026-09-08 | GSE346029 | GEO
UnknownThe ubiquitin-specific protease USP36 is a conserved histone H2B deubiquitinase.
Not available
S-EPMC5771408 | biostudies-literature
TranscriptomicsThe function of USP36 in the ER positive Breast Cancer
To investigate the function of USP36 in the ER positive Breast Cancer.
ORGANISM(S): Homo sapiens 
2024-04-01 | GSE262678 | GEO
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