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SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system
ORGANISM(S): Drosophila melanogaster 
Progenitor cells at the basal layer of skin epidermis play an essential role in maintaining tissue homeostasis and enhancing wound repair in skin. The proliferation, differentiation, and cell death of epidermal progenitor cells have to be delicately regulated, as deregulation of this process can lea...
ORGANISM(S): Homo sapiens (Human) 
2020-05-13 | PXD015673 | Pride
USP37 Promotes Deubiquitination of HIF2a in Kidney Cancer
USP13 Promotes Deubiquitination of ZHX2 and Tumorigenesis in Kidney Cancer
CRISPR-Cas9 screen to identify PD-L1 positive or negative E3 ligase or deubiquitination enzyme

BACKGROUND: Cryopyrin-Associated Periodic Syndrome (CAPS) is an autoinflammatory condition consequence of monoallelic variants in the NLRP3 gene that exacerbate IL-1β production. These variants are gain-of-function, but the exact regulatory mechanism of the NLRP3 CAPS-inflammasom...

2024-01-09 | MTBLS7872 | MetaboLights
CDC6 is an oncogenic protein whose expression level fluctuates during the cell cycle. Although several E3 ubiquitin ligases responsible for the ubiquitin-mediated proteolysis of CDC6 have been identified, the deubiquitination pathway for CDC6 has not been investigated. Here, we report that OTUD6A fu...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042935 | Pride
Dual roles of the Arabidopsis PEAT complex in histone H2A deubiquitination and H4K5 acetylation [RNA-seq]
Dual roles of the Arabidopsis PEAT complex in histone H2A deubiquitination and H4K5 acetylation [ChIP-seq]
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