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MetabolomicsAbsorption efficiency of RESV through mouse skin using 3 bases in different tissues
Resveratrol (RESV) is a plant polyphenol, which is thought to have beneficial metabolic effects in laboratory animals as well as in humans. Following oral administration, RESV is immediately catabolized, resulting in low bioavailability. This study compared RESV metabolites and their tissue distribu...
2014-12-15 | MTBLS126 | MetaboLights
MetabolomicsDistribution of RESV and its metabolite peaks in mouse tissues after oral and skin administration
Resveratrol (RESV) is a plant polyphenol, which is thought to have beneficial metabolic effects in laboratory animals as well as in humans. Following oral administration, RESV is immediately catabolized, resulting in low bioavailability. This study compared RESV metabolites and their tissue distribu...
2014-12-15 | MTBLS125 | MetaboLights
MetabolomicsEarly-life skin molecular signatures are predictive of atopic dermatitis risk in an Asian preconception birth cohort
Rationale: Early identification of infants at risk for atopic dermatitis (AD) is critical for timely prevention, yet robust preclinical biomarkers remain elusive. We characterized the longitudinal evolution of the skin microbiome, metabolome, and proteome to identify molecular signatures predictive ...
2026-10-05 | MTBLS14496 | MetaboLights
MetabolomicsMetabolic Reprogramming and Reliance in Human Skin Wound Healing
Impaired skin wound healing is a significant global health issue, especially among the elderly. Wound healing is a well-orchestrated process involving the sequential phases of inflammation, proliferation, and tissue remodeling. Although wound healing is a highly dynamic and energy-requiring process,...
2024-07-02 | MTBLS3315 | MetaboLights
MetabolomicsInvestigating the effects of circadian rhythm on the human skin lipidome

The circadian rhythm is a 24 h cycle that harmonises the activity of organs – including the skin – to a daily routine using neurological and hormonal signals. Limited research has been done to understand the effects of the circadian rhythm on the skin lipidome. We used reverse...

2025-10-17 | MTBLS12607 | MetaboLights
MetabolomicsStudy on the Effect of Bee Venom and Its Main Component melittin In Delaying Skin Aging in Mice
Bee venom (BV) and its main compound melittin (MLT) have antioxidant, anti-inflammatory, and anti-aging activities; however, very little research has been conducted on their effects on skin aging. In this study, a mouse skin aging model induced by D-galactose (D-gal) was constructed via subcutaneous...
2025-05-12 | MTBLS11975 | MetaboLights
MetabolomicsDecipher aging related skin microbiome and metabolites crosstalk from a chronologically matched cohort

Aging has shown close link to shifts in the skin microbiome in population cohort study. However, how variations in microbial communities relate to divergent skin aging within individuals of the same chronological ages remains unclear. In this study, we performed phenotypic, metabolomic and metage...

2025-01-03 | MTBLS11994 | MetaboLights
MetabolomicsComprehensive transcriptome and metabolome analysis revealed the primary molecular regulatory pathways of skin development in Yulin black duck during embryonic stage
Skin color is one of the key characteristics the duck possesses which is used to determine the market value because it affects the consumer's purchasing decisions. People tend to prefer ducks with black skin because they are more suitable for making soup. This study was conducted to identify the sig...
2026-08-24 | MTBLS14916 | MetaboLights
MetabolomicsDifferentiating Hemorrhagic Shock and Organophosphate Poisoning through Integrated Skin Microbiome–Metabolome Signatures

Accurate determination of cause of death and estimation of postmortem interval (PMI) are critical yet challenging tasks in forensic science, particularly in cases with rapid demise and minimal gross findings. We employed an integrative multi-omics approach to characterize postmortem microbial suc...

2026-06-01 | MTBLS14219 | MetaboLights
MetabolomicsSelective galactose culture condition reveals distinct metabolic signatures in pyruvate dehydrogenase and complex I deficient human skin fibroblasts

INTRODUCTION: A decline in mitochondrial function represents a key factor of a large number of inborn errors of metabolism, which lead to an extremely heterogeneous group of disorders.

OBJECTIVES: To gain insight into the biochemical consequences of mitocho...

2021-10-06 | MTBLS761 | MetaboLights
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