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ProteomicsDeubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance
CDC6 is an oncogenic protein whose expression level fluctuates during the cell cycle. Although several E3 ubiquitin ligases responsible for the ubiquitin-mediated proteolysis of CDC6 have been identified, the deubiquitination pathway for CDC6 has not been investigated. Here, we report that OTUD6A fu...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042935 | Pride
Otud6a Deubiquitinase Hek293 
ProteomicsOTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR
To explore the underlying mechanism by which OTUD6A induces PCa progression, we identified its binding proteins with an immunoprecipitation (IP)-mass spectrometry (MS) approach in two CRPC cell lines.
ORGANISM(S): Homo Sapiens 
2022-01-28 | PXD031307 |
GenomicsProstate-specific Oncogene OTUD6A Promotes Prostatic Tumorigenesis via Deubiquitinating and Stabilizing c-Myc
Prostate-specific Oncogene OTUD6A Promotes Prostatic Tumorigenesis via Deubiquitinating and Stabilizing c-Myc
PRJNA784264 | ENA
GenomicsDeubiquitinase OTUD6A in macrophages promotes intestinal inflammation and colitis via deubiquitination of NLRP3
Deubiquitinase OTUD6A in macrophages promotes intestinal inflammation and colitis via deubiquitination of NLRP3
PRJNA930387 | ENA
UnknownDeubiquitinase OTUD6A Regulates Innate Immune Response via Targeting UBC13
Not available
S-EPMC10458163 | biostudies-literature
UnknownOTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR.
Not available
S-EPMC8888634 | biostudies-literature
TranscriptomicsDeubiquitinase OTUD6A in macrophages promotes intestinal inflammation and colitis via deubiquitination of NLRP3
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, which has been shown to increase the incidence of colorectal cancer. Recent studies have highlighted the role of ubiquitination, a post-translational modification, in the occurrence and development of ...
ORGANISM(S): Mus musculus 
2023-04-01 | GSE224239 | GEO
TranscriptomicsProstate-specific Oncogene OTUD6A Promotes Prostatic Tumorigenesis via Deubiquitinating and Stabilizing c-Myc
In this study, we found that OTUD6A is a physiological deubiquitinase for c-Myc in prostate cancer setting and promotes prostatic tumorigenesis through stabilizing c-Myc oncoprotein. Moreover, knockout of Otud6a in mice retarded the prostatic tumorigenesis in Hi-Myc prostate cancer mice model
ORGANISM(S): Mus musculus 
2022-01-01 | GSE189716 | GEO
UnknownDeubiquitinase OTUD6A in macrophages promotes intestinal inflammation and colitis via deubiquitination of NLRP3.
Not available
S-EPMC10244424 | biostudies-literature
UnknownDeubiquitinase OTUD6A alleviates acetaminophen-induced liver injury by targeting EZH2 to reduce cell death in hepatocytes.
Not available
S-EPMC12491687 | biostudies-literature
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