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ProteomicsEvidence for an RNAi-independent role of DICER-LIKE2 in conferring growth inhibition and basal antiviral resistance
Higher plants encode four or five DICER-LIKE (DCL) enzymes responsible for the production of small non-coding RNAs which function in RNA interference (RNAi). Different RNAi pathways in plants effect transposon silencing, antiviral defense and endogenous gene regulation. DCL2 acts genetically redunda...
ORGANISM(S): Arabidopsis Thaliana 
PXD046163 | panorama
TranscriptomicsGene expression profiles of Six1/2-1(RNAi) animals and POU2/3(RNAi) animals
The goal of this study was to identify genes that were expressed in the protonephridial system. Because Six1/2(RNAi) and POU2/3(RNAi) animals lose the tubules, flame cells and accessory cells, these animals were expected to show decreased levels of the genes expressed in the nephridial system relati...
ORGANISM(S): Schmidtea mediterranea 
2011-11-28 | E-GEOD-31618 | biostudies-arrayexpress
TranscriptomicsThe RDE-10/RDE-11 complex triggers RNAi induced mRNA degradation by association with target mRNA in C. elegans
The molecular mechanisms for target mRNA degradation in C. elegans undergoing RNA interference (RNAi) are not fully understood. Using a combination of genetic, proteomic and biochemical approaches, we report a divergent RDE-10/RDE-11 complex that is required for RNAi in C. elegans. The RDE-10/RDE-...
ORGANISM(S): Caenorhabditis elegans 
2012-04-25 | E-GEOD-36494 | biostudies-arrayexpress
TranscriptomicsThe impact of RNAi on the Saccharomyces castellii transcriptome
RNAi, a gene-silencing pathway triggered by double-stranded RNA, is conserved in diverse eukaryotic species but has been lost in the model budding yeast, Saccharomyces cerevisiae. We report that RNAi is present in other budding-yeast species, including Saccharomyces castellii and Candida albicans. ...
ORGANISM(S): Naumovozyma castellii 
2009-09-10 | E-GEOD-17870 | biostudies-arrayexpress
TranscriptomicsRNAi triggered by specialized machinery silences developmental genes and retrotransposons (ChIP-chip)
RNAi is a conserved mechanism in which small interfering RNAs (siRNAs) guide the degradation of cognate RNAs, but also promote heterochromatin assembly at repetitive DNA elements such as centromeric repeats. However, the full extent of RNAi functions and its endogenous targets have not been explored...
ORGANISM(S): Schizosaccharomyces pombe 
2012-11-26 | E-GEOD-41642 | biostudies-arrayexpress
TranscriptomicsRNAi mediates post-transcriptional repression of gene expression in fission yeast Schizosaccharomyces pombe [Illumina Genome Analyzer]
RNA interference (RNAi) is a gene silencing mechanism conserved from fungi to mammals. Small interfering RNAs are products and mediators of the RNAi pathway and act as specificity factors in recruiting effector complexes. The Schizosaccharomyces pombe genome encodes one of each of the core RNAi prot...
ORGANISM(S): Schizosaccharomyces pombe 972h- 
2014-01-23 | E-GEOD-54194 | biostudies-arrayexpress
TranscriptomicsThe Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification
From a forward genetic screen for C. elegans genes required for RNAi, we identified rde-10 and through proteomic analysis of RDE-10-interacting proteins, we identified a protein complex containing the new RNAi factor RDE-11, the known RNAi factors RSD-2 and ERGO-1, as well as other candidate RNAi fa...
ORGANISM(S): Caenorhabditis elegans 
2012-04-07 | E-GEOD-37083 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse ES cells after control RNAi (scramble siRNAs) or specific RNAi (siRNAs for specific genes) treatment
To address the functional role of MOF in mammalian X upregulation, male and female mouse ES cells were transfected with a mixture of three small interfering RNA duplexes, each of which targets a different region of Mof mRNA. We found that MOF knockdown in mouse ES cells caused a greater drop in expr...
ORGANISM(S): Mus musculus 
2013-02-15 | E-GEOD-44252 | biostudies-arrayexpress
GenomicsSolanum lycopersicum strain:RNAi SlSUC
Solanum lycopersicum strain:RNAi SlSUC Raw sequence reads
PRJNA480740 | ENA
TranscriptomicsRNAseq in whole freshwater planarians, Schmidtea mediterranea, following RNAi of the transcription factors lhx1/5-1 and pitx.
Freshwater planarians can be used as a model to investigate neuronal function and maintenance in adults in vivo. We knocked down expression for 2 transcription factors, then sequenced resulting animals to examine transcriptional changes that may have occurred. There are 3 triplicated conditions: c...
ORGANISM(S): Schmidtea mediterranea 
2013-05-31 | E-GEOD-47348 | biostudies-arrayexpress
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