robo2 signaling

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CD47 activates ROBO2 signaling to regulate glioblastoma cell plasticity and metabolism

PRJNA1190393 | ENA

CD47 stabilizes ROBO2 to regulate glioblastoma progression by preventing ITCH mediated ubiquitination

CD47 is a key innate immune checkpoint that inhibits phagocytosis by myeloid cells, contributing to immune evasion by cancer cells. Although CD47-blocking antibodies have shown promise in treating various malignancies, their efficacy in glioblastoma (GBM) remains limited, and the cell-intrinsic role...

ORGANISM(S): Homo sapiens (Human)

2026-03-05 | PXD071366 | Pride

SLIT/ROBO2 signaling promotes mammary stem cell senescence by inhibiting Wnt signaling.

Not available

S-EPMC4266005 | biostudies-literature

Disruption of Robo2-Baiap2 integrated signaling drives cystic disease.

Not available

S-EPMC6795383 | biostudies-literature

SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion.

Not available

S-EPMC5111509 | biostudies-literature

CD47 activates ROBO2 signaling to regulate glioblastoma cell plasticity and metabolism

CD47 inhibits phagocytosis by myeloid cells, contributing to immune evasion by cancer cells. Although CD47-blocking antibodies have shown promise in treating various malignancies, their efficacy in glioblastoma (GBM) remains limited, and the role of CD47 beyond immune escape is poorly understood. He...

ORGANISM(S): Homo sapiens

2026-03-09 | GSE282771 | GEO

N-cadherin acts in concert with Slit1-Robo2 signaling in regulating aggregation of placode-derived cranial sensory neurons.

Not available

S-EPMC2781051 | biostudies-literature

Robo2 and Gen1 Coregulate Ureteric Budding by Activating the MAPK/ERK Signaling Pathway in Mice.

Not available

S-EPMC8766746 | biostudies-literature

Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization.

Not available

S-EPMC4819398 | biostudies-literature

Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure.