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ProteomicsN-terminal pyroglutamate in CD47 is involved in SIRPα interactions
T-cell immune checkpoint inhibitors have revolutionized cancer immunotherapy. In addition to T cells, immune checkpoint molecules have also been described for myeloid cells, with CD47 on tumor cells and Signal Regulatory Protein α (SIRPα) on effector cells being the most established example (Maute e...
ORGANISM(S): Homo sapiens (Human) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2026-05-19 | PXD066444 | Pride
Pglu Therapeutic antibodies Cd47 Signal regulatory protein α (sirpα) Glutaminyl-peptide cyclotransferase-like (qpctl) 
TranscriptomicsCD47 Inhibits Self-renewal and Reprogramming by Regulating c-Myc and Other Stem Cell Transcription Factors
Signaling through the thrombospondin-1 receptor CD47 broadly limits cell and tissue survival of stress, but the molecular mechanisms are incompletely understood. We now show that loss of CD47 permits sustained proliferation of primary murine endothelial cells and enables these cells to spontaneously...
ORGANISM(S): Mus musculus 
2013-07-10 | E-GEOD-43133 | biostudies-arrayexpress
ProteomicsCD47 interactions with exportin-1 regulate targeting of m7G-capped RNAs to extracellular vesicles
CD47 is a marker of self and a signaling receptor for thrombospondin-1 that is also a membrane component of extracellular vesicles (EVs) released by various cell types. Previous studies identified CD47-dependent functional effects of EVs on target cells, mediated by delivery of their RNA contents, a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-01 | MSV000086969 | MassIVE
GenomicsClostridioides difficile CD47
Clostridioides difficile CD47 Genome sequencing and assembly
PRJNA85713 | ENA
ProteomicsHDX-MS Analysis of CD47 Conformational Dynamics
CD47 is the only 5-transmembrane (5-TM) spanning receptor of the immune system. Its extracellular domain (ECD) is a cell surface ‘marker of self’ that binds SIRPα and inhibits macrophage phagocytosis, and cancer immuno-therapy approaches in clinical trials are focused on blocking CD47/SIRPα interact...
ORGANISM(S): Homo sapiens (Human) 
2021-07-15 | PXD026458 | Pride
Hdx-ms Cd47 
TranscriptomicsExpression data comparing Huh7 control and CD47 knockdown cells
To identify candidate genes regulated by CD47 Affymetrix Human Genome U133 Plus GeneChip 2.0 HCC cell line Huh7 cells with or without CD47 repressed
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-47563 | biostudies-arrayexpress
ProteomicsCD47 stabilizes ROBO2 to regulate glioblastoma progression by preventing ITCH mediated ubiquitination
CD47 is a key innate immune checkpoint that inhibits phagocytosis by myeloid cells, contributing to immune evasion by cancer cells. Although CD47-blocking antibodies have shown promise in treating various malignancies, their efficacy in glioblastoma (GBM) remains limited, and the cell-intrinsic role...
ORGANISM(S): Homo sapiens (Human) 
2026-03-05 | PXD071366 | Pride
Cd47  glioblastoma  robo2 signaling  ubiquitination  q exactive hf hybrid quadrupole-orbitrap  e3 ubiquitin ligase itch 
ProteomicsCD47 blocking antibody confers metabolic protective effects by promoting AMPK activation in skeletal muscle
Our study investigated the impact of CD47 gene deletion on protein acetylation and its regulatory effects on mitochondrial metabolism and function in the skeletal muscle of mice.
ORGANISM(S): Mus musculus (Mouse) 
2025-02-27 | PXD061117 | Pride
Cd47 blocking antibody Ampk Skeletal muscle Mitochondrial energetic 
GenomicsCD47 in the tumor microenvironment and CD47 antibody blockade regulate natural killer cell recruitment and activation
CD47 in the tumor microenvironment and CD47 antibody blockade regulate natural killer cell recruitment and activation
PRJNA454315 | ENA
TranscriptomicsCD47-dependent immunomodulatory and angiogenic activities of extracellular vesicles produced by T cells
Intercellular communication is critical for integrating complex signals in multicellular eukaryotes. Vascular endothelial cells and T lymphocytes closely interact during the recirculation and trans-endothelial migration of T cells. In addition to direct cell-cell contact, we show that T cell deriv...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-56825 | biostudies-arrayexpress
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