Pglu - OmicsDI

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Proteomics (4)
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Organisms

Alphavirus (3)
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Eukaryota (3)
Hepatitis B virus (3)
Human alphaherpesvirus 1 (3)
Human betaherpesvirus 5 (3)
Influenza A virus (3)
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Japanese encephalitis virus group (3)
Kamptonema sp. (3)
Listeria monocytogenes (3)
Mammarenavirus (3)
Miscanthus x giganteus (3)
Mycobacterium tuberculosis (3)
Orthoflavivirus (3)
Pseudomonas aeruginosa (3)
Rattus (3)
Sarbecovirus (3)
Severe acute respiratory syndrome coronavirus 2 (3)
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Drosophila melanogaster (2)
Homo sapiens (1)

Organisms

Homo sapiens (1)

Repository

pride (3)
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geo (1)
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Tissue

Cell culture (1)
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Saliva (1)

Disease

Cystic fibrosis (1)

Technology Type

Mass Spectrometry (3)
Bottom-up proteomics (2)
Data-dependent acquisition (2)
Mass spectrometry assay (1)
Gel-based experiment (1)
Top-down proteomics (1)

Instrument Platform

Q Exactive (1)
Liquid Chromatography MS - positive - reverse-phase (1)
Liquid Chromatography MS - negative - reverse-phase (1)

Publication Date

2026 (3)
2012 (1)
2010 (1)
2021 (1)
2019 (1)
2017 (1)

CHEBI ID

CHEBI:32220 (1)
CHEBI:51148 (1)
CHEBI:53405 (1)
CHEBI:233526 (1)
CHEBI:90873 (1)
CHEBI:143097 (1)
CHEBI:91399 (1)
CHEBI:230729 (1)
CHEBI:58354 (1)
CHEBI:132810 (1)
CHEBI:193189 (1)
CHEBI:16146 (1)
CHEBI:173243 (1)
CHEBI:28787 (1)
CHEBI:615597 (1)
CHEBI:170067 (1)
CHEBI:49284 (1)
CHEBI:183868 (1)
CHEBI:6802 (1)
CHEBI:89809 (1)
CHEBI:32664 (1)
CHEBI:27454 (1)
CHEBI:83067 (1)
CHEBI:173533 (1)
CHEBI:35702 (1)
CHEBI:57926 (1)
CHEBI:5738 (1)
CHEBI:167175 (1)
CHEBI:746917 (1)
CHEBI:137944 (1)

Metabolite Name

Γ-Linolenic acid (1)
VS1180000 (1)
MFCD11045308 (1)
MFCD00209536 (1)
Methyl (2E,4Z)-2,4-hexadecadienoate (1)
Ethanoic anhydride (1)
CP 47,497-C6-Homolog (1)
3-{[3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]amino}-2-[(3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)amino]propanenitrile (non-preferred name) (1)
2,6-di-tert-Butyl-4-methoxyphenol (1)
1-(5-Hydroxy-3a,4-dimethyl-3a,4,5,6,7,7a-hexahydro-1H-inden-2-yl)ethanone (1)
1-(4-Methoxyphenyl)-3-pentanone (1)
(6Z)-9-Hydroxy-3,6,10-trimethyl-3a,4,5,8,9,10,11,11a-octahydrocyclodeca[b]furan-2(3H)-one (1)
(6E,9Z,12E)-6,9,12-Pentadecatrien-2-one (1)
(2Z)-2-(2-Ethoxy-2-oxoethylidene)succinic acid (1)
(2E)-2-[(3E)-4,8-Dimethyl-10-oxo-3,7-cyclodecadien-1-ylidene]propanal (1)
(1E)-5-(2+3:7-Hydroxy-2-propanyl)-2-methyl-8-methylene-7-oxo-1-cyclodecen-1-yl acetate (1)
3-acetamidopropanal (1)
1-(Propyldisulfanyl)-1-(propylsulfinyl)propane (1)
Pyroglutamylglycine (1)
DL-β-Leucine (1)
Α,α-Trehalose (1)
3-Hydroxypentadecanoic acid (1)
(+/-)-Gingerol (1)
L-(+)-Erythrulose (1)
2-Hydroxy-4-oxopentanoic acid (1)
Benzyl chloride (1)
4-tert-Octylphenol (1)
L-(+)-Lactic acid (1)
Cis-7-Hexadecenoic acid (1)
L-(+)-Aspartic acid (1)

First Public Date

2024 (1)

Study type

Unknown experiment type (1)
Transcription profiling by array (1)

Release Date

2024 (8)
2021 (6)
2022 (5)
2025 (3)
2015 (3)
2012 (2)
2010 (2)
2020 (2)
2019 (2)
2017 (2)
2016 (2)
2014 (2)
2011 (2)
2023 (1)
2013 (1)
2006 (1)
2005 (1)
2001 (1)

Lab affiliation

Department of Life and Environmental Sciences, Biomedical Section, University of Cagliari, Monserrato, CA, Italy. (1)
Division of Stem Cell Transplantation and Cellular Immunotherapies, Department of Medicine II, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany (1)
the Scripps Research Institute (1)

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N-terminal pyroglutamate in CD47 is involved in SIRPα interactions

T-cell immune checkpoint inhibitors have revolutionized cancer immunotherapy. In addition to T cells, immune checkpoint molecules have also been described for myeloid cells, with CD47 on tumor cells and Signal Regulatory Protein α (SIRPα) on effector cells being the most established example (Maute e...

ORGANISM(S): Homo sapiens (Human) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

2026-05-19 | PXD066444 | Pride

Expression of a triple mutational des-pGlu brazzein in transgenic mouse milk.

Not available

S-EPMC9249319 | biostudies-literature

PGlu-Modified Nanocrystalline Cellulose Improves Mechanical Properties, Biocompatibility, and Mineralization of Polyester-Based Composites.

Not available

S-EPMC6829302 | biostudies-literature

The Antagonist pGlu-βGlu-Pro-NH2 Binds to an Allosteric Site of the Thyrotropin-Releasing Hormone Receptor.

Not available

S-EPMC8433856 | biostudies-literature

Glutaminyl cyclase (QC) activity affects gene expression in macrophages during inflammation

Glutaminyl cyclase (QC) activity in macrophage cells is correlated with the gene expression of MCP-2 and QC-catalyzed N-terminal pGlu formation of MCPs is required for macrophage migration and provide new insights into the role of QC in the inflammation process.

ORGANISM(S): Homo sapiens

2021-10-22 | GSE21082 | GEO

An artifact in LC-MS/MS measurement of glutamine and glutamic acid: in-source cyclization to pyroglutamic acid.

Not available

S-EPMC4063328 | biostudies-literature

Linked production of pyroglutamate-modified proteins via self-cleavage of fusion tags with TEV protease and autonomous N-terminal cyclization with glutaminyl cyclase in vivo.

Not available

S-EPMC3986218 | biostudies-literature

Abundant pyroglutamate-modified ABri and ADan peptides in extracellular and vascular amyloid deposits in familial British and Danish dementias.

Not available

S-EPMC3570712 | biostudies-literature

Computational Studies on the Mechanisms of Nonenzymatic Intramolecular Cyclization of the Glutamine Residues Located at N-Termini Catalyzed by Inorganic Phosphate Species.