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TranscriptomicsDeficiency in the multicopy Sycp3-like X-linked genes Slx and Slxl1 causes major defects in spermatid differentiation
The gene Sly is present in multiple copies on the mouse Y chromosome and encodes a protein that is required for the epigenetic regulation of postmeiotic sex chromosome expression. The X chromosome carries two multicopy genes related to Sly: Slx and Slxl1. Here we investigate the role of Slx/Slxl1 us...
ORGANISM(S): Mus musculus 
2011-05-11 | E-GEOD-29197 | biostudies-arrayexpress
TranscriptomicsExpression data of pachytene spermatocytes and round spermatids from young and aged Brown Norway rats
Male fertility and testis function changes with age and so it was sought to determine if these changes are accompanied by changes in gene expression. A full genome microarray was used to determine if distinct pathways of genes were altered in expression in germ cells (pachytene spermatocytes or roun...
ORGANISM(S): Rattus norvegicus 
2012-01-06 | E-GEOD-29963 | biostudies-arrayexpress
TranscriptomicsRound Spermatids and Pachytene Spermatocytes
Mouse Round Spermatids (Sptd) and Pachytene Spermatocytes (Spcy)
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-1768 | biostudies-arrayexpress
GenomicsPaternally inherited H3K27me3 affects chromatin accessibility in mouse embryos produced by round spermatid injection
Paternally inherited H3K27me3 affects chromatin accessibility in mouse embryos produced by round spermatid injection
PRJNA807595 | ENA
GenomicsPaternally inherited H3K27me3 impacts zygotic genome activation in round spermatid injection [RNA-seq]
Paternally inherited H3K27me3 impacts zygotic genome activation in round spermatid injection [RNA-seq]
PRJNA807596 | ENA
GenomicsPaternally inherited H3K27me3 impacts zygotic genome activation in round spermatid injection [ATAC-seq]
Paternally inherited H3K27me3 impacts zygotic genome activation in round spermatid injection [ATAC-seq]
PRJNA807599 | ENA
TranscriptomicsExpression data from 30do mouse spermatid [Affymetrix]
Chromatin performs numerous functions during cellular differentiation, and therefore it must be capable of adopting a multitude of different structures. How these various structures are established is poorly understood, but we propose that specific histone H2A variants will have a key role in remode...
ORGANISM(S): Mus musculus 
2012-01-20 | E-GEOD-29781 | biostudies-arrayexpress
GenomicsPaternally inherited H3K27me3 affects chromatin accessibility in mouse embryos produced by round spermatid injection
Round spermatid injection (ROSI) results in a lower birth rate than intracytoplasmic sperm injection, which has hampered its clinical application. Inefficient development of ROSI embryos has been attributed to epigenetic abnormalities. However, the chromatin-based mechanism that underpins the low bi...
ORGANISM(S): Mus musculus 
2022-08-22 | GSE196859 | GEO
TranscriptomicsExpression data from purified control and BrdtΔBD1 round spermatids.
Brdt is a testis specific member of a family of chromatin interacting proteins. All of the family members have been shown to regulate transcription. Brdt is highly expressed in round spermatids, and may play a role in transcriptional regulation in these cells. We investigated transcriptional changes...
ORGANISM(S): Mus musculus 
2011-10-20 | E-GEOD-33132 | biostudies-arrayexpress
TranscriptomicsExpression data from E12.5 male fatal PGCs, PGCLC in vitro, round spermatids and spermatids like cells produced in vitro
Generation of haploid gametes in vitro can potentially address gamete failure-based infertility.This study reports complete in vitro meiosis from murine ESC-derived PGCLCs resulting in the formation of male spermatid-like cells (SLCs) capable of producing viable fertile offspring via intracytoplasmi...
ORGANISM(S): Mus musculus 
2016-02-26 | E-GEOD-71478 | biostudies-arrayexpress
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