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Coilin and Pol II ChIP-seq in HeLa cells after RPL14 and RPL24 depletion
To investigate location of Cajal bodies (CB) inside the cell nucleus after RPL depletion, we performed ChIP-seq with an anti-Coilin antibody after siRNA knockdown of RPL14 and RPL24. ChIP-seq revealed a loss of association of CBs wih snRNA genes and histone genes in histone cluster 1 and 2 upon RPL ...
ORGANISM(S): Homo sapiens 
2024-03-27 | GSE199275 | GEO
The goal of this experiment was to compare the genes expressed in malignant peripheral nerve sheath tumors (MPNSTs) that arise in zebrafish as a result of homozygous mutation of the p53 gene or heterozygous mutation of several different ribosomal protein (rp) mutations. Since MPNSTs arise very rare...
ORGANISM(S): Danio rerio 
Imatinib (IM), a tyrosine kinase inhibitor (TKI), has markedly improved the survival and life quality of chronic myeloid leukemia (CML) patients. However, the lack of specific biomarkers for IM resistance remains a serious clinical challenge. Recently, growing evidence has suggested that exosome-harb...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028779 | Pride
Background: In the early stage of embryonic development, the neural tube (NT) cannot be closed properly due to some complex factors such as, environmental factors, genetic factors and the relationship between various factors, leading to the occurrence of neural tube defects (NTDs). Methods: In this...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-12 | PXD045752 | Pride
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