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RUVBL1 and RUVBL2 are druggable MYCN regulators in neuroblastoma
To investigate the role of RUVBL1/2 in neuroblastoma, we performed siRNA-mediated knockdown of RUVBL1 and RUVBL2 in CLB-BAR cells. Cells were transfected with Silencer Select siRNAs (Life Technologies) targeting RUVBL1 (ID S16369 and S16370) or RUVBL2 (ID S21307 and S21309) or a non-targeting scramb...
ORGANISM(S): Homo sapiens 
siRNA-mediated knockdown of RUVBL1 and RUVBL2 in CLB-BAR neuroblastoma cells
RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer
RUVBL1 promotes enzalutamide resistance of prostate tumors through the PLXNA1-CRAF-MAPK pathway
To understand its role RUVBL1/2 in neuroblastoma, we inhibited RUVBL1/2 ATPase activity two independent cell lines, SK-N-AS and CBL-BA, with 250 nM CB-6644 at 0, 24, 48, and 72 hrs and performed RNA sequencing.
ORGANISM(S): Homo sapiens 
RUVBL1 and RUVBL2 (collectively RUVBL1/2) are essential AAA+ ATPases that function as co-chaperones and have been implicated in cancer. Here we investigated the molecular and phenotypic role of RUVBL1/2 ATPase activity in non-small cell lung cancer (NSCLC). We find that RUVBL1/2 are overexpressed in...
ORGANISM(S): Homo sapiens 
2019-12-18 | GSE107637 | GEO
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