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ProteomicsIdentification of SAMD9 and SAMD9L interactome in HEK293T cells
Recently, heterozygous germline mutations were identified in sterile alpha motif (SAM) domain-9 (SAMD9) and its paralog, SAMD9-like (SAMD9L) in children with monosomy 7 mediated MDS. Expression of SAMD9 and SAMD9L is induced by interferons and other inflammatory stimuli and causes reduced cell divis...
ORGANISM(S): Homo sapiens (Human) 
2021-03-24 | PXD020018 | Pride
Samd9  samd9l  pediatric mds  proteomics 
GenomicsFunctional Assessment of Inherited Myeloid Neoplasm-Associated SAMD9L Germline Variants via Monoallelic CRISPR Modeling
Functional characterization of SAMD9L mutations
PRJEB105420 | ENA
GenomicsIn vivo expression of mutant Samd9l collaborates with inflammation to induce bone marrow failure
In vivo expression of mutant Samd9l collaborates with inflammation to induce bone marrow failure
PRJNA789872 | ENA
GenomicsIn vivo expression of mutant Samd9l collaborates with inflammation to induce bone marrow failure. [RNA-Seq]
In vivo expression of mutant Samd9l collaborates with inflammation to induce bone marrow failure. [RNA-Seq]
PRJNA787569 | ENA
TranscriptomicsIn vivo expression of mutant Samd9l collaborates with inflammation to induce bone marrow failure
SAMD9 and SAMD9L germline mutations have recently emerged as a new class of predispositions to pediatric myeloid neoplasms. Patients commonly have hypocellular bone marrows and a greater risk of developing clonal chromosome 7 deletions. We recently demonstrated that expressing SAMD9/SAMD9L mutations...
ORGANISM(S): Mus musculus 
2022-10-08 | GSE191147 | GEO
UnknownIdentification of CP77 as the Third Orthopoxvirus SAMD9 and SAMD9L Inhibitor with Unique Specificity for a Rodent SAMD9L.
Not available
S-EPMC6613757 | biostudies-literature
TranscriptomicsIn vivo expression of mutant Samd9l collaborates with inflammation to induce bone marrow failure. [RNA-Seq]
SAMD9 and SAMD9L germline mutations have recently emerged as a new class of predispositions to pediatric myeloid neoplasms. Patients commonly have hypocellular bone marrows and a greater risk of developing clonal chromosome 7 deletions. We recently demonstrated that expressing SAMD9/SAMD9L mutations...
ORGANISM(S): Mus musculus 
2022-10-08 | GSE190566 | GEO
UnknownFunctional Study of SAMD9L in Familial Gastric Cancer.
Not available
S-EPMC10334681 | biostudies-literature
UnknownGermline SAMD9L truncation variants trigger global translational repression.
Not available
S-EPMC7970252 | biostudies-literature
GenomicsPediatric MDS-Associated Germline Mutations in SAMD9 and SAMD9L Impair Multiple Pathways in Primary Hematopoietic Cells
Pediatric MDS-Associated Germline Mutations in SAMD9 and SAMD9L Impair Multiple Pathways in Primary Hematopoietic Cells
PRJNA639279 | ENA
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