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ProteomicsIdentification of SAMD9 and SAMD9L interactome in HEK293T cells
Recently, heterozygous germline mutations were identified in sterile alpha motif (SAM) domain-9 (SAMD9) and its paralog, SAMD9-like (SAMD9L) in children with monosomy 7 mediated MDS. Expression of SAMD9 and SAMD9L is induced by interferons and other inflammatory stimuli and causes reduced cell divis...
ORGANISM(S): Homo sapiens (Human) 
2021-03-24 | PXD020018 | Pride
Samd9  samd9l  pediatric mds  proteomics 
TranscriptomicsAnalysis of undifferentiated hiPSC and differentiation into intermediate mesoderm of cells from patients carrying a heterozygous mutation in the SAMD9 gene
hiPSC were derived from fibroblasts of two patients carrying a heterozygous mutation in the SAMD9 gene. The patients have a multisystem disorder of intrauterine growth restriction (IUGR) with gonadal, adrenal and bone marrow failure and high mortality. To examine a potential influence of the SAMD9 m...
ORGANISM(S): Homo sapiens 
2017-06-02 | E-MTAB-5145 | biostudies-arrayexpress
GenomicsTranscriptional responses to SAMD9 overexpression in A549 cells
Transcriptional responses to SAMD9 overexpression in A549 cells
PRJNA951052 | ENA
GenomicsHuman SAMD9 is a Virus-Activatable Anticodon Nuclease Inhibiting Codon-Specific Protein Synthesis
Human SAMD9 is a Virus-Activatable Anticodon Nuclease Inhibiting Codon-Specific Protein Synthesis
PRJNA957283 | ENA
TranscriptomicsTranscriptional responses to SAMD9 overexpression in A549 cells
The goal of this study is to use RNA-sequencing to profile the transcriptional changes in A549 cells with SAMD9 overexpression by plasmid transfection. Specifically, we were interested in determining the interferons and chemokines induced by SAMD9 overexpression. We observed that each of the type II...
ORGANISM(S): Homo sapiens 
2024-12-31 | GSE228684 | GEO
GenomicsHuman SAMD9 is a Poxvirus-Activatable Anticodon Nuclease Inhibiting Codon-Specific Protein Synthesis
Human SAMD9 is a Poxvirus-Activatable Anticodon Nuclease Inhibiting Codon-Specific Protein Synthesis
PRJNA956925 | ENA
GenomicsStructure and Function of an Effector Domain in Antiviral Factors and Tumor Suppressors SAMD9 and SAMD9L
Structure and Function of an Effector Domain in Antiviral Factors and Tumor Suppressors SAMD9 and SAMD9L
PRJNA773935 | ENA
GenomicsOverexpression of human SAMD9 inhibits protein translation and alters MYC signaling resulting in cell cycle arrest
Overexpression of human SAMD9 inhibits protein translation and alters MYC signaling resulting in cell cycle arrest
PRJNA1124154 | ENA
TranscriptomicsHuman SAMD9 is a Poxvirus-Activatable Anticodon Nuclease Inhibiting Codon-Specific Protein Synthesis
As a defense strategy against viruses or competitors, some microbes employ anticodon nucleases (ACNases) to deplete essential tRNAs, effectively halting global protein synthesis. However, this mechanism has not been observed in multicellular eukaryotes. Here, we report that human SAMD9 is an ACNase ...
ORGANISM(S): Homo sapiens 
2023-06-07 | GSE229979 | GEO
TranscriptomicsOverexpression of human SAMD9 inhibits protein translation and alters MYC signaling resulting in cell cycle arrest
Inherited bone marrow failure syndromes (iBMFS) often result from pathogenic mutations in genes that are important for ribosome function, namely, Diamond-Blackfan anemia, Shwachman-Diamond syndrome, and dyskeratosis congenita. Germline mutations in SAMD9 are a frequent genetic lesion resulting in an...
ORGANISM(S): Homo sapiens 
2025-05-07 | GSE269946 | GEO
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