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MetabolomicsEvaluation of sample preparation protocols for quantitative NMR-based metabolomics

INTRODUCTION: Quantification of metabolites in biological fluids and tissues by NMR spectroscopy is challenged by the presence of abundant macromolecules and lipoproteins in samples, which give broad signals in the NMR spectra. To improve the quality of NMR spectra the different ...

2024-07-11 | MTBLS847 | MetaboLights
MetabolomicsEvaluation of sample preparation methods for NMR-based metabolomics of cow milk
The quality of milk metabolome analyzed by nuclear magnetic resonance (NMR) is greatly influenced by the way samples are prepared. Although this analytical method is increasingly used to study milk metabolites, a thorough examination of available sample preparation protocols for milk has not been re...
2019-06-13 | MTBLS623 | MetaboLights
MetabolomicsSample Preparation for Integrated Metabolome and Exposome-Wide Association Studies (MWAS/ExWAS)

Exposome- and metabolome-wide association studies rely on advanced instrumentation, typically anchored in liquid chromatography high-resolution mass spectrometry (LC-HRMS) to investigate exposure-effect associations. Sample preparation for biological fluids is a delicate matter since it is essent...

2026-07-20 | MTBLS15100 | MetaboLights
MetabolomicsEvaluation of Sample Preparation Methods for the Analysis of Reef-Building Corals Using 1H-NMR-based Metabolomics
The field of metabolomics generally lacks standardized methods for the preparation of samples prior to analysis. This is especially true for metabolomics of reef-building corals, where the handful of studies that have been published employ a range of sample preparation protocols. The utilization of ...
2019-03-20 | MTBLS862 | MetaboLights
MetabolomicsAssessment of human plasma and urine sample preparation for re-producible and high-throughput UHPLC-MS clinical metabolic phenotyping

Clinical metabolic phenotyping employs metabolomics and lipidomics to detect and measure thousands of metabolites and lipids within human samples. This approach aims to identify metabolite and lipid changes between phenotypes (e.g. disease status) that aid understanding of biochemical mechanisms ...

2020-08-06 | MTBLS1465 | MetaboLights
MetabolomicsUntargeted metabolomics workshop report: quality control considerations from sample preparation to data analysis

The Metabolomics workshop on experimental and data analysis training for untargeted metabolomics was hosted by the Proteomics Society of India in December 2019. The Workshop included six tutorial lectures and hands-on data analysis training sessions presented by seven speakers. The tutorials and ...

2020-12-17 | MTBLS1301 | MetaboLights
MetabolomicsMatrix Effect on Chemical Isotope Labeling and Its Implication in Metabolomic Sample Preparation for Quantitative Metabolomics
Matrix effect from various constituents in biological samples can reduce the accuracy of quantitative metabolomics. Differential chemical isotope labeling liquid chromatography mass spectrometry (CIL LC-MS) can overcome the matrix effect on MS detection based on measuring the intensity ratios of met...
2015-07-01 | MTBLS194 | MetaboLights
MetabolomicsA Taguchi Design of Experiments Approach for Untargeted Metabolomics Sample Preparation Optimization
Not available
ORGANISM(S): Caenorhabditis elegans 
ST002046 | MetabolomicsWorkbench
MetabolomicsEvaluation of metabolome sample preparation and extraction methodologies for oleaginous filamentous fungi Mortierella alpina
Not available
ORGANISM(S): Mortierella alpina 
ST001141 | MetabolomicsWorkbench
MetabolomicsGC-XLE method development: dSPE and MgSO4 as clean-up for sample preparation
Not available
ORGANISM(S): Homo sapiens 
ST001787 | MetabolomicsWorkbench
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