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ProteomicsLabel-free quantitative (LFQ) proteomic analysis of redox mediated posttranslational modifications (PTM) in the cartilage from young and old osteoarthritis (OA) mice with or without the senolytic treatment
Senolytic drugs are designed to selectively clear senescent cells (SnCs) that accumulate with injury or aging. In a mouse model of osteoarthritis (OA), senolysis yields a pro-regenerative response. However, recent research studies showed that the therapeutic benefit is reduced in aged mice. Increase...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-26 | PXD031782 | Pride
Mouse model of osteoarthritis (oa)  senolytic treatment  label-free quantitative (lfq) proteomic  analysis of redox ptms in the cartilage proteins 
GenomicsSenolytic treatment alleviates doxorubicin-induced chemobrain
Senolytic treatment alleviates doxorubicin-induced chemobrain
PRJNA990762 | ENA
GenomicsChemo-senolytic therapeutic potential against angiosarcoma
Chemo-senolytic therapeutic potential against angiosarcoma
PRJNA1030406 | ENA
ProteomicsMulti-omics profiling reveals systemic rejuvenation of the aged kidney through senolytic therapy
Cellular senescence is a key driver of kidney aging, leading to functional decline and increased susceptibility to chronic kidney disease. While the senolytic combination of dasatinib and quercetin (D+Q) has shown promise in mitigating age-related pathologies, its long-term effects and underlying mu...
ORGANISM(S): Homo Sapiens 
2026-03-24 | PXD076057 |
Genomics
Senolytic treatment in osteoarthritis
PRJNA1331506 | ENA
UnknownChronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.
Not available
S-EPMC5013022 | biostudies-literature
GenomicsSenolytic treatments in physiologically-aged human brain organoids
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology
PRJEB58180 | ENA
TranscriptomicsChemo-senolytic therapeutic potential against angiosarcoma
Angiosarcoma is an aggressive soft-tissue sarcoma with a poor prognosis. Chemotherapy for this cancer typically employs paclitaxel, one of the taxanes (genotoxic drugs), although it has a limited effect due to chemoresistance for prolonged treatment. Here we examine a new angiosarcoma treatment appr...
ORGANISM(S): Homo sapiens 
2024-03-23 | GSE245935 | GEO
GenomicsDasatinib and quercetin senolytic treatment delays progression of disc degeneration in SM/J mice
Dasatinib and quercetin senolytic treatment delays progression of disc degeneration in SM/J mice
PRJNA1183349 | ENA
UnknownImpact of Senolytic Treatment on Gene Expression in Aged Lung.
Not available
S-EPMC10145650 | biostudies-literature
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