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ProteomicsProteomic analysis in mouse liver
Protein SUMOylation is crucial in both physiological and pathological contexts, but its role in acute liver injury is poorly understood. We found that SENP3, a SUMO2/3 protease, rapidly accumulates in hepatocytes around the pericentral vein zone within 2 hours of CCl₄-induced liver injury in mice. K...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-09 | PXD065391 | Pride
Proteomic  senp3  liver 
ProteomicsSUMOylation proteomic analysis in mouse liver
Protein SUMOylation is crucial in both physiological and pathological contexts, but its role in acute liver injury is poorly understood. We found that SENP3, a SUMO2/3 protease, rapidly accumulates in hepatocytes around the pericentral vein zone within 2 hours of CCl₄-induced liver injury in mice. K...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-09 | PXD065419 | Pride
Senp3 Protein sumoylation Liver 
GenomicsSENP3 Drives HCC Redox Adaptation via THRAP3/NRF1 Axis
SENP3 Drives HCC Redox Adaptation via THRAP3/NRF1 Axis
PRJNA1244237 | ENA
GenomicsSENP3 Drives HCC Redox Adaptation via THRAP3/NRF1 Axis [RNA-Seq]
SENP3 Drives HCC Redox Adaptation via THRAP3/NRF1 Axis [RNA-Seq]
PRJNA1245269 | ENA
ProteomicsIdentification of SENP3 and SENP5 target proteins by endogenous SUMO2/3 IP-MS
Ribosome biogenesis is a complex and energy demanding process requiring tight coordination with cell growth and proliferation. Impairment of ribosome biogenesis activates a well-defined cell-cycle checkpoint that primarily relies on the activation of p53 signaling. However, there is mounting evidenc...
ORGANISM(S): Homo sapiens (Human) 
2023-10-28 | PXD037793 | Pride
Sumo Human Senp Lc-ms/ms 
GenomicsSENP3-mediated host defense response contains HBV replication and restores protein synthesis
SENP3-mediated host defense response contains HBV replication and restores protein synthesis
PRJNA505306 | ENA
OtherSENP3 Drives HCC Redox Adaptation via THRAP3/NRF1 Axis
SENP3 drives oxidative stress adaptation and ferroptosis resistance in HCC via THRAP3-mediated activation of NRF1. Targeting SENP3 with LNPs not only inhibits tumor progression but also enhances the efficacy of lenvatinib. These findings suggest SENP3 as a promising therapeutic target and biomarker ...
ORGANISM(S): Homo 
2026-09-30 | GSE293352 | GEO
TranscriptomicsSENP3 Drives HCC Redox Adaptation via THRAP3/NRF1 Axis [RNA-Seq]
SENP3 drives oxidative stress adaptation and ferroptosis resistance in HCC via THRAP3-mediated activation of NRF1. Targeting SENP3 with LNPs not only inhibits tumor progression but also enhances the efficacy of lenvatinib. These findings suggest SENP3 as a promising therapeutic target and biomarker ...
ORGANISM(S): Homo sapiens 
2026-09-30 | GSE293566 | GEO
GenomicsSENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions(ChIP-seq)
SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions(ChIP-seq)
PRJNA808419 | ENA
GenomicsSENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions(RNA-seq)
SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions(RNA-seq)
PRJNA808418 | ENA
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