SENP3 Drives HCC Redox Adaptation via THRAP3/NRF1 Axis

ABSTRACT: SENP3 drives oxidative stress adaptation and ferroptosis resistance in HCC via THRAP3-mediated activation of NRF1. Targeting SENP3 with LNPs not only inhibits tumor progression but also enhances the efficacy of lenvatinib. These findings suggest SENP3 as a promising therapeutic target and biomarker for redox-based and ferroptosis-combined therapies in HCC.

ORGANISM(S): Homo

PROVIDER: GSE293352 | GEO | 2026/09/30

REPOSITORIES: GEO