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MetabolomicsSuccinate accumulation drives ischaemia-reperfusion injury during organ transplantation
During heart transplantation, storage in cold preservation solution is thought to protect the organ by slowing metabolism; by providing osmotic support; and by minimising ischaemia-reperfusion (IR) injury upon transplantation into the recipient. Despite its widespread use, our understanding of the m...
2019-09-20 | MTBLS1085 | MetaboLights
ProteomicsProteomic profiling of AML patient-derived xenografts across serial transplantation
This dataset contains mass spectrometry-based proteomic profiling of acute myeloid leukemia patient-derived xenograft samples collected across serial transplantation stages. The study aimed to characterize proteome remodeling associated with leukemia propagation and disease evolution in AML PDX mode...
ORGANISM(S): Homo sapiens (Human) 
2026-07-20 | PXD078079 | Pride
Acute myeloid leukemia  aml  patient-derived xenograft  pdx  serial transplantation  proteomics  mass spectrometry  leukemia stem cells 
GenomicsSingle-cell RNA-seq profiling of AML patient-derived xenografts across serial transplantation
Single-cell RNA-seq profiling of AML patient-derived xenografts across serial transplantation
PRJNA1462256 | ENA
GenomicsscRNA-Seq analysis of HSC, MPP1 and MPP2 cells after serial transplantation of miR-221/222-proficient and deficient HSC.
scRNA-Seq analysis of HSC, MPP1 and MPP2 cells after serial transplantation of miR-221/222-proficient and deficient HSC.
PRJNA944643 | ENA
TranscriptomicsSingle-cell RNA-seq profiling of AML patient-derived xenografts across serial transplantation
Single-cell RNA sequencing was performed on AML PDX samples across serial transplantation (P0, P1, P2) to investigate transcriptional evolution and leukemic stem cell dynamics.
ORGANISM(S): Homo sapiens 
2026-07-20 | GSE329946 | GEO
TranscriptomicsscRNA-Seq analysis of HSC, MPP1 and MPP2 cells after serial transplantation of miR-221/222-proficient and deficient HSC.
We have studied the effect of miR-221/222-deficiency on early hematopoietic stem and progenitor compartments after serial transplantation of miRNA-proficient and deficient HSC.
ORGANISM(S): Mus musculus 
2023-08-21 | GSE227322 | GEO
GenomicsTranscriptome profiling of SW480 cells and cells derived from xenograft tumors from serial transplantation of SW480 cells by RNA-sequencing
Transcriptome profiling of SW480 cells and cells derived from xenograft tumors from serial transplantation of SW480 cells by RNA-sequencing
PRJNA791300 | ENA
TranscriptomicsFrizzled 4 regulates stemness and invasiveness of migrating glioma cells established by serial in vivo intracranial transplantation
One of the most detrimental hallmarks of glioblastoma multiforme (GBM) is cellular invasiveness, considered a potential cause of tumor recurrence. Infiltrated GBM cells are difficult to completely eradicate surgically and with local therapeutic modalities. Although much effort has focused on unders...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-21570 | biostudies-arrayexpress
TranscriptomicsSerial xenotransplantation in NSG mice promotes a hybrid epithelial/mesenchymal gene expression signature and stemness in rhabdomyosarcoma cells
NSTS-11 cell line derived from a primary embryonal rhabdomyosarcoma was used for serial xenotransplantation in NSG mice in vivo. Subsequently, three cell lines, LTB1, LTB5, and LTB24, were derived from primary, secondary, and tertiary xenograft tumors, respectively. Gene expression profiling of all...
ORGANISM(S): Homo sapiens 
2019-04-30 | E-MTAB-7664 | biostudies-arrayexpress
GenomicsModeling Canine B-cell Lymphoma Complexity Through Serial Transplantation in Immunodeficient Mice
Modeling Canine B-cell Lymphoma Complexity Through Serial Transplantation in Immunodeficient Mice
PRJNA1390674 | ENA
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