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GenomicsSerine/Threonine phosphatase PP2A is essential for optimal B cell function
Serine/Threonine phosphatase PP2A is essential for optimal B cell function
PRJNA604601 | ENA
ProteomicsPhosphatase POPX2 exhibits dual regulatory functions in cancer metastasis
Cancer metastasis is a complex mechanism involving multiple processes. In an earlier study, we reported that the levels of serine/threonine phosphatase POPX2were positively correlated with cancer cell motility through modulating MAPK signaling. Surprisingly, here we found that POPX2 knockdown cells ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080801 | MassIVE
OtherAlterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients.
Data from ProteomeXchange, PXD ID: PXD000697. Exiperiment: PP1_Mouse_raw_IgG, file: OR8_121211_NL_DC_PP1_Gel4_B_labelfree2.mzml. Published as part of J Am Coll Cardiol. 2015 Jan 20;65(2):163-73 . From the Abstract: {{i}} Cardiac lysates were coimmunoprecipitated with anti-PP1c antibody followed by ...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320014437 | GPMDB
Resource Reanalysis 
ProteomicsQuantitative chemical proteomic profiling of phosphoprotein phosphatases
We have developed a chemical proteomic strategy for the systematic interrogation of endogenous phosphoprotein phosphatases (PPP) and their interacting proteins, including regulatory and scaffolding subunits, and substrates (the 'PPPome'). PPPs are captured using an immobilized non-selective PPP inhi...
ORGANISM(S): Neurospora Crassa (ncbitaxon:5141) Candida Albicans (ncbitaxon:5476) Saccharomyces Cerevisiae (ncbitaxon:4932) Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) Schizosaccharomyces Pombe (ncbitaxon:4896) 
2017-07-07 | MSV000081226 | MassIVE
ProteomicsThe C. elegans ASPP homolog APE-1 is a junctional Protein Phosphatase 1 modulator
Protein samples were analyzed by Multidimensional Protein Identification Technology (MudPIT), as described previously. Briefly, precipitated proteins were resuspended in 30uL of 100mM Tris pH 8.5 with 8M urea to denature proteins. Cysteines were reduced and alkylated prior to digestion with recombi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Caenorhabditis Elegans (ncbitaxon:6239) 
2022-02-04 | MSV000088781 | MassIVE
ProteomicsComparative Phenotypic, Proteomic, and Phosphoproteomic Analysis Reveals Different Roles of Serine/Threonine Phosphatase and Kinase in the Growth, Cell Division, and Pathogenicity of Streptococcus suis
To investigate the influence of STP and STK on protein expression in S. suis, we performed a comparative proteomics analysis with the WT, Δstp, and Δstk strains using liquid chromatography mass spectrometry/mass spectrometry (LC-MS/MS).STK and STP are serine/threonine kinases and phosphatases, respe...
ORGANISM(S): Streptococcus suis SC84 
2021-11-30 | PXD029994 | Pride
Streptococcus suis  serine/threonine phosphatase  serine/threonine kinase  coordinated regulation  growth  cell division  pathogenicit 
ProteomicsAurora B opposes PP1 function in mitosis through phosphorylation of the conserved RVxF binding motif in PP1 regulatory proteins
Protein phosphatase 1 (PP1) is a highly conserved protein phosphatase that opposes the actions of a diverse set of Ser-Thr protein kinases by controlling the majority of serine-threonine (Ser-Thr) dephosphorylation reactions in eukaryotes. PP1 gains substrate specificity through binding to a large n...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-03-30 | MSV000082226 | MassIVE
TranscriptomicsSerine/Threonine phosphatase PP2A is essential for optimal B cell function
Protein phosphatase 2A (PP2A), a serine/threonine phosphatase, has been shown to control T cell function. We found that in vitro activated B cells and B cells from various lupus-prone mice and patients with systemic lupus erythematosus display increased PP2A activity. To understand the contribution ...
ORGANISM(S): Mus musculus 
2020-02-04 | GSE144700 | GEO
ProteomicsAlterations in the Interactome of Serine/Threonine Protein Phosphatase Type-1 in Atrial Fibrillation Patients
Objectives: To test the hypothesis that serine/threonine protein phosphatase type-1 (PP1) is dysregulated in paroxysmal atrial fibrillation (pAF) at the level of its regulatory subunits (R-subunits). Background: AF is the most common sustained cardiac arrhythmia yet current pharmacologic treatment i...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2015-03-30 | PXD000697 | Pride
Human Label-free quantification Q-exactive Mouse Protein phosphatase 1 Paroxysmal atrial fibrillation Ltq-orbitrap elite 
UnknownMycobacterial phosphatase PstP regulates global serine threonine phosphorylation and cell division.
Not available
S-EPMC6554272 | biostudies-literature
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