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TranscriptomicsRNA seq of MLL-ENL transformed cells under serine/glycine starvation including a starvation resistant clone
Primary hematopoietic cells were transformed by retrovirally transduced MLL-ENL. The resulting cell population was either cultured in full medium or under starvation conditions without serine and glycine. In addition a spontaneously arising ser/gly starvation resistant clone was included in this exp...
ORGANISM(S): Mus musculus 
2021-06-21 | E-MTAB-8738 | biostudies-arrayexpress
TranscriptomicsAmino acid deprivation due to overexpression of UCP1 in skeletal muscle: signalling via FGF-21
Recent studies on mouse and human skeletal muscle (SM) demonstrated the important link between mitochondrial function and the cellular metabolic adaptation. To identify key compensatory molecular mechanisms in response to chronic mitochondrial distress, we analyzed mice with ectopic SM respiratory u...
ORGANISM(S): Mus musculus 
2015-02-17 | E-GEOD-45991 | biostudies-arrayexpress
MetabolomicsSerine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism and mTORC1 signaling

Cells use glycolytic intermediates for anabolism e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation. The first aim of this study was therefore to identify enzymes tha...

2025-03-21 | MTBLS8854 | MetaboLights
UnknownSerine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy.
Not available
S-EPMC7809039 | biostudies-literature
UnknownBioinformatics analysis of the serine and glycine pathway in cancer cells.
Not available
S-EPMC4294344 | biostudies-literature
ProteomicsRaw data for manuscript : "Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD"
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects one third of the global population. Understanding metabolic pathways involved can provide insights into disease progression and treatment. Untargeted metabolomics of livers from mice with early-stage steatosis uncovered decreas...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-12-12 | MSV000093653 | MassIVE
TranscriptomicsTranscription profiling of murine embryonic head Phgdh knock outs
D-3-Phosphoglycerate dehydrogenase (Phgdh; EC 1.1.1.95) is a necessary enzyme for de novo L-serine biosynthesis via the phosphorylated pathway. We demonstrated previously that Phgdh is expressed exclusively by neuroepithelium and radial glia in developing mouse brain and later mainly by astrocytes. ...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-8555 | biostudies-arrayexpress
TranscriptomicsEnergy Metabolism during Anchorage-Independence
The detachment of epithelial cells, but not cancer cells, causes anoikis due to reduced energy production. Invasive tumor cells generate three splice variants of the metastasis gene osteopontin. The cancer-specific form osteopontin-c supports anchorage-independence through inducing oxidoreductases a...
ORGANISM(S): Homo sapiens 
2014-02-21 | E-GEOD-55193 | biostudies-arrayexpress
TranscriptomicsThe effects of ectopic UCP1 expression on gene expression in skeletal muscle
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-02-19 | E-GEOD-45993 | biostudies-arrayexpress
UnknownMetabolic Reprogramming by MYCN Confers Dependence on the Serine-Glycine-One-Carbon Biosynthetic Pathway.
Not available
S-EPMC6679782 | biostudies-literature
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