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TranscriptomicsEffect of SF3A1 inhibition on pre-mRNA splicing
We previously found that the SF3A mRNA splicing complex was required for a robust innate immune response; SF3A acts in part by inhibiting the production of a negatively acting splice form of the TLR signaling adaptor MyD88. Here we inhibit SF3A1 using RNAi and subsequently perform an RNAseq study to...
ORGANISM(S): Mus musculus 
2015-02-09 | E-GEOD-58432 | biostudies-arrayexpress
ProteomicsSequence specific recognition of U1 snRNP stem-loop 4 by the ubiquitin-like domain of U2 snRNP protein SF3A1 and its RGG motif
Cross-linking of isotope-labelled RNA coupled with mass spectrometry (CLIR-MS) was used to study the interaction between the ubiquitin-like domain (UBL) of the protein SF3A1, a component of the U2 snRNP, with stem-loop 4 RNA (SL4) from the U1 snRNP. The complex was cross-linked and analysed both in ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD027189 | Pride
Uv cross-linking  sf3a1  u1  u2  snrnp  splicing  spliceosome  structural proteomics  protein-rna  rna-protein  protein-rna complex  rna-protein complex  clir-ms 
UnknownIdentification of a noncanonical RNA binding domain in the U2 snRNP protein SF3A1.
Not available
S-EPMC6795144 | biostudies-literature
UnknownThe Associations between RNA Splicing Complex Gene SF3A1 Polymorphisms and Colorectal Cancer Risk in a Chinese Population.
Not available
S-EPMC4469430 | biostudies-literature
UnknownSF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer.
Not available
S-EPMC4741962 | biostudies-literature
TranscriptomicsEffect of SF3A1 inhibition on pre-mRNA splicing
We previously found that the SF3A mRNA splicing complex was required for a robust innate immune response; SF3A acts in part by inhibiting the production of a negatively acting splice form of the TLR signaling adaptor MyD88. Here we inhibit SF3A1 using RNAi and subsequently perform an RNAseq study to...
ORGANISM(S): Mus musculus 
2015-02-09 | GSE58432 | GEO
UnknownStem-loop 4 of U1 snRNA is essential for splicing and interacts with the U2 snRNP-specific SF3A1 protein during spliceosome assembly.
Not available
S-EPMC4233244 | biostudies-literature
GenomicsMus musculus
Effect of SF3A1 inhibition on pre-mRNA splicing
PRJNA252602 | ENA
TranscriptomicsSplicing Factor 3a Subunit 1 Promotes Colorectal Cancer Growth via Anti-programmed cell death of Syntaxin12.
SF3A1 is a subunit of the SF3a complex, an integral component of U2 snRNP, playing a crucial role in intron recognition and pre-RNA splicing during the splicing process. Notably, we observed that SF3A1 exerts its growth-promoting effects specifically in cancer cells, despite no discernible alteratio...
ORGANISM(S): Homo sapiens 
2026-02-18 | GSE282463 | GEO
UnknownStructural basis for the interaction between the first SURP domain of the SF3A1 subunit in U2 snRNP and the human splicing factor SF1.
Not available
S-EPMC9514218 | biostudies-literature
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