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TranscriptomicsTranscriptome and microRNA array analyses reveal a stimulatory effect of the phytochemical shikonin on epithelial–mesenchymal transition (EMT) in mouse skin [microRNA expression profile]
We investigate and define here the in vivo biological effects of shikonin, at the transcriptome and microRNA levels, in mouse skin tissues. Through cross-examination between total RNA transcripts and microRNA data sets, we predicted that shikonin treatment may affect the epithelial–mesenchymal trans...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-32695 | biostudies-arrayexpress
TranscriptomicsTranscriptome and microRNA array analyses reveal a stimulatory effect of the phytochemical shikonin on epithelial–mesenchymal transition (EMT) in mouse skin
This SuperSeries is composed of the following subset Series: GSE32694: Transcriptome and microRNA array analyses reveal a stimulatory effect of the phytochemical shikonin on epithelial–mesenchymal transition (EMT) in mouse skin [gene expression profile] GSE32695: Transcriptome and microRNA array ana...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-32696 | biostudies-arrayexpress
TranscriptomicsExpression profile of shikonin resistant K562 cell line
After over 25cycle and 18month's induction of shikonin, K562 cell show maginal resistance to shikonin but great change in gene expression We use microarray to detect the global gene expression change of shikonin resistant cell K562 cell was treated by 4uM shikonin for 4hours, then allowed to die and...
ORGANISM(S): Homo sapiens 
2011-12-10 | E-GEOD-34298 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing reveals immune microenvironment changes induced by Fe-Shikonin treatment in SCC7 tumors
Single-cell RNA sequencing was performed on tumor tissues obtained from SCC7-bearing C3H mice to investigate the effects of Fe-Shikonin treatment on the tumor immune microenvironment. Tumor samples were collected from a phosphate-buffered saline (PBS)-treated control group and a Fe-Shikonin-treated ...
ORGANISM(S): Mus musculus 
2026-05-30 | E-MTAB-16487 | biostudies-arrayexpress
TranscriptomicsTranscriptome and microRNA array analyses reveal a stimulatory effect of the phytochemical shikonin on epithelial–mesenchymal transition (EMT) in mouse skin [gene expression profile]
We investigate and define here the in vivo biological effects of shikonin, at the transcriptome and microRNA levels, in mouse skin tissues. Through cross-examination between total RNA transcripts and microRNA data sets, we predicted that shikonin treatment may affect the epithelial–mesenchymal trans...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-32694 | biostudies-arrayexpress
TranscriptomicsRNA-seq of AD patient-derived induced neurons treated with shikonin
We have obtained fibroblast cultures from old adult human control donors and Alzheimer patients. The fibroblasts were reprogrammed into directly induced neurons (iNs) to serve as an adult-like and age-equivalent model for aging and neurodegeneration. iNs were treated for 10 days with 10 µM shikonin ...
ORGANISM(S): Homo sapiens 
2022-07-02 | E-MTAB-11855 | biostudies-arrayexpress
ProteomicsEffect of Shikonin on Aspergillus terreus
Aspergillus terreus is an emerging fungal pathogen in immunocompromised patients. Due to intrinsic resistance of AmB against A. terreus and acquiring resistance to azoles, alternative antifungal strategy needs investigation. Thus, we explored the activity of phytochemicals such as Shikonin, gallic a...
ORGANISM(S): Aspergillus terreus 
2021-06-19 | PXD016797 | Pride
Amphotericin b  catalase  shikonin  gallic acid  biofilm  oxidative stress 
TranscriptomicsEffects of shikonin on the gene expression of human lymphoma U937 cells
Shikonin is a active component isolated from the roots of the traditional Chinese herb Lithospermum erythrorhizon and exhibits multiple pharmacological properties, such as anti-oxidant, anti-inflammatory, and anti-tumor effects. Here, the effects of shikonin on the gene expression of human lymphoma ...
ORGANISM(S): Homo sapiens 
2010-10-20 | E-GEOD-24743 | biostudies-arrayexpress
GenomicsShikonin inhibit progression of colon cancer
Shikonin inhibit progression of colon cancer
PRJNA982801 | ENA
GenomicsInhibitory effect of shikonin on lung cancer cells
Inhibitory effect of shikonin on lung cancer cells
PRJNA922941 | ENA
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