Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of rat adrenal glands from spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto animals
We measured gene expression in the adrenal glands of the Spontaneously Hypertensive Rat (SHR) and Wistar-Kyoto rat (WKY) using Affymetrix RG-U34A GeneChips. All rats were aged-matched at 4-weeks. The rats were obtained from the colonies at the Univeristy of California San Diego, La Jolla, CA.
ORGANISM(S): Rattus norvegicus 
2007-11-01 | E-GEOD-1675 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hypertensive and normotensive rats treated with the AT1 receptor antagonist candesartan and vehicle
In hypertension, abnormal regulation of microcirculation and endothelial dysfunction enhances vulnerability to hypertensive brain damage. In addition to lowering blood pressure, blockade of Angiotensin II AT1 receptors protects against stroke and stress in different animal models and this treatment ...
ORGANISM(S): Rattus norvegicus 
2007-11-03 | E-GEOD-2739 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat left ventricular samples from 12-, 16- and 20-month old spontaneously hypertensive rats (SHRs) compared with age-matched Wistar-Kyoto (WKY) rats as controls
Left ventricular gene expression profiles from 12-, 16- and 20-months old spontaneously hypertensive rats (SHRs) were compared with left ventricular profiles seen in age-matched Wistar-Kyoto (WKY) rats [control rats] by screening Affymetrix U34A arrays (there are 4 samples in each timepoint except 3...
ORGANISM(S): Rattus norvegicus 
2007-09-20 | E-GEOD-2116 | biostudies-arrayexpress
TranscriptomicsGene expression in the adrenal glands of two spontaneously hypertensive rat strains at 3 and 6 weeks of age
We examined gene expression profiles in the rat adrenal glands using genome-wide microarray technology, and determined gene expression profiles in 3 rat strains: normotensive WKY, spontaneously hypertensive rats (SHR), and stroke-prone SHR (SHRSP). To identify candidate genes involved in the genesis...
ORGANISM(S): Rattus norvegicus 
2013-04-16 | E-GEOD-31457 | biostudies-arrayexpress
TranscriptomicsGene expression in the whole brains of two spontaneously hypertensive rat strains at 3 and 6 weeks of age
We examined gene expression profiles in the rat whole brains using genome-wide microarray technology, and determined gene expression profiles in 3 rat strains: normotensive WKY, spontaneously hypertensive rats (SHR), and stroke-prone SHR (SHRSP). To identify candidate genes involved in the genesis o...
ORGANISM(S): Rattus norvegicus 
2014-01-24 | E-GEOD-41452 | biostudies-arrayexpress
TranscriptomicsDifferential Renal Gene Expression in Pre-hypertensive and Hypertensive SHR
This study examined the renal gene expression profiles between spontaneously-hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats at a pre-hypertensive stage (3 weeks of age) and hypertensive stage (9 weeks of age). In addition, age-related changes in gene expression patterns were examined from 3 to...
ORGANISM(S): Rattus norvegicus 
2010-06-05 | E-GEOD-1932 | biostudies-arrayexpress
MetabolomicsA Mechanistic Study on the Synergistic Antihypertensive Effects of Dendrobium officinale Compound Combined with Conventional Antihypertensive Drugs in Spontaneously Hypertensive Rats, Based on Metabolomics
This dataset comprises metabolomic profiling data of serum and gut metabolites from 6 female Wistar rats and 42 female spontaneously hypertensive rats (SHR). Six Wistar rats were assigned to the normal control group (Normal), and 42 SHR rats were randomly divided into seven groups with six rats in e...
2026-05-18 | MTBLS14513 | MetaboLights
TranscriptomicsPleiotropic effects of metformin on inflammation, oxidative and dicarbonyl stress in transgenic spontaneously hypertensive rats expressing human C-reactive protein.
Inflammation, oxidative and dicarbonyl stress play important roles in the pathophysiology of type 2 diabetes. Metformin is the first-line drug of choice for the treatment of type 2 diabetes because it effectively suppresses gluconeogenesis in the liver, however, its “pleiotropic“ effects remain cont...
ORGANISM(S): Rattus norvegicus 
2016-07-03 | E-MTAB-3791 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of kidney from rats of SHR/Ola, BN and SHR-18 strains after being provided with drinking water with 1% or 0% sodium chloride
Four male SHR/Ola, BN and SHR-18 rats were fed a normal diet and sacrificed at 9 weeks of age. Four male SHR/Ola and SHR-18 rats at 8 weeks of age were fed 1% NaCl for one week and then sacrificed. Kidneys were removed and frozen in liquid nitrogen for all 20 animals. Total RNA was isolated, labelle...
ORGANISM(S): Rattus norvegicus 
2008-04-01 | E-MIMR-1122 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat resistance artery in 2 models of hypertension
We investigated morphometric structure and gene expression by microarray analysis in a small diameter artery, branch of the saphenous artery (a resistance artery), in representative models of renin-angiotensin system (RAS)-dependent and glucocorticoid hypertension, using the spontaneously hypertensi...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-8051 | biostudies-arrayexpress
Sort   by:  
 Page size