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ProteomicsPlasma Proteomic Characterization of Colorectal Cancer Patients with FOLFOX Chemotherapy
Colorectal Cancer (CRC) is one of most common cancers in the world and a main treatment in postoperative chemotherapy is oxaliplatin and fluorouracil (FOLFOX), But the effect is different among CRC patients. In this study, LC-MS/MS strategy was used to profile the plasma proteome in FOLFOX benefit a...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD044201 | Pride
Human plasma proteome  sisprot  lc-ms/ms  random forest  prm validation 
ProteomicsAn integrated strategy for high-sensitive and multi-level glycoproteome analysis from low micrograms of protein samples
In this study, we aimed to develop a simple and integrated spintip-based glycoproteomics technology, termed Glyco-SISPROT, for challenging the lowest starting material limitation and achieving comprehensive view of glycoproteome with shortest sample processing time. By carefully integrating and opti...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-03-14 | MSV000083570 | MassIVE
ProteomicsAn integrated strategy for high-sensitive and multi-level glycoproteome analysis from low micrograms of protein samples
We describe here a simple and integrated spintip-based glycoproteomics technology,termed Glyco-SISPROT, for challenging the lowest starting material limitation and achieving a comprehensive view of glycoproteome with shortest sample processing time. By carefully integrating and optimizing SCX, C18 a...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-03-15 | MSV000083579 | MassIVE
Proteomics[HPP-2.0] Combinatory strategy using nanoscale proteomics and machine learning for T cell subtyping in peripheral blood of single multiple myeloma patients
In this study, we combined flow cytometry with the simple integrated spintip-based proteomics technology (SISPROT) to characterize the proteome of primary T cell subtypes in the peripheral blood (PB) from single multiple myeloma (MM) patients.
ORGANISM(S): Homo Sapiens 
2024-02-04 | PXD049159 |
ProteomicsAn integrated strategy for high-sensitive and multi-level glycoproteome analysis from low micrograms of protein samples
Glycosylation, as a biologically important protein post-translational modification, often alters on both glycosites and glycans, simultaneously. However, most of current approaches focused on biased profiling of either glycosites or glycans, and limited by time-consuming process and milligrams of st...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-03-25 | MSV000083630 | MassIVE
ProteomicsSpatial Tumor Proteome Profiling by Immunohistochemistry-Based Laser Capture Microdissection and Data-Independent Proteomics
We designed an immunohistochemistry (IHC)-based workflow for cell type-resolved proteome analysis of tissue samples. Firstly, targeted cell type was marked by IHC using antibody targeting cell-type specific marker to improve accuracy and efficiency of LCM. Secondly, to increase protein recovery from...
ORGANISM(S): 9606 
2020-03-20 | MSV000085131 | MassIVE
ProteomicsIntegrated strategy for high-sensitive phosphoproteome analysis from low micrograms of protein samples
In this study, we aimed to challenge the lowest starting material limit for phosphoproteome profiling. By carefully optimizing the well-established high-pH reversed-phase (RP) fractionation plus Ti4+-IMAC enrichment strategy, we achieved the identification of 15260 and 8936 unique phosphopeptides fr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-06-04 | MSV000082435 | MassIVE
UnknownPlasma proteomic characterization of colorectal cancer patients with FOLFOX chemotherapy by integrated proteomics technology.
Not available
S-EPMC10998366 | biostudies-literature
ProteomicsHigh-throughput drug target discovery by fully automated proteomics sample preparation platform
Drug development is plagued by inefficiency and high costs due to issues such as inadequate drug efficacy and unexpected toxicity. Mass spectrometry (MS)-based proteomics, particularly isobaric quantitative proteomics, offers a solution to unveil resistance mechanisms and unforeseen side effects rel...
ORGANISM(S): Homo sapiens (Human) 
2024-01-16 | PXD044006 | Pride
Fully automated， high-throughput drug target discovery 
ProteomicsTargeting Prolyl 3-hydroxylase 1 Inhibits Pancreatic Cancer Progression and Macrophage Immunity
Using transcriptome sequencing, proteomic analyses and engineered mouse model, we have revealed a novel and pivotal role of Prolyl 3-hydroxylase 1 (P3H1) in PDAC. The expression of P3H1 is elevated in PDAC and correlates with poor outcomes in human patients. The genetic deletion of P3H1 in KPC mouse...
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD070325 | Pride
P3h1 Plk1 Chemotherapy Tumor microenvironment Pancreatic ductal adenocarcinoma 
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