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GenomicsmRNA sequencing of SKMEL28 cells
mRNA sequencing of SKMEL28 cells
PRJNA752118 | ENA
TranscriptomicsmiR-146a promotes the initiation and progression of melanoma by activating Notch signaling
Oncogenic mutations in BRAF and NRAS occur in 70% of melanomas. Here we identify a microRNA, miR-146a, that is highly upregulated by oncogenic BRAF and NRAS. Expression of miR-146a increases the ability of human melanoma cells to proliferate in culture and form tumors in mice, whereas knockdown of m...
ORGANISM(S): Homo sapiens 
2014-02-18 | E-GEOD-39294 | biostudies-arrayexpress
TranscriptomicsmRNA sequencing of SKMEL28 cells
A RNA-seq analysis was performed to characterize the molecular intermediates responsible for the deleterious effects upon DUSP4 loss in SKMEL28 cells. Methods:SKMEL28 cells were transfected with siRNA against DUSP4 or non-targeting control with or without Trametinib (Tram) at 0.25nM. After 16 hours,...
ORGANISM(S): Homo sapiens 
2022-04-22 | GSE181467 | GEO
TranscriptomicsGene expression profiling of melanoma cells following intracardiac injection in NOD-SCID mice: a comprehensive in vivo model
To evaluate the in vivo metastatic activity of five different melanoma cell lines (LCP, LCM, WM266, SKMel28 and A375), we completed intra-cardiac injection of 1x106 luminescent cells in NOD-SCID mice. All melanoma cell lines demonstrated a metastatic behaviour following intra-cardiac injection with ...
ORGANISM(S): Homo sapiens 
2026-02-23 | E-MTAB-16710 | biostudies-arrayexpress
GenomicsRNA-seq analysis of SKMEL28 melanoma cells following DIRC3 and IGFBP5 ASO knockdown
RNA-seq analysis of SKMEL28 melanoma cells following DIRC3 and IGFBP5 ASO knockdown
PRJNA531445 | ENA
GenomicsGene expression data in total mRNA from human SKMEL28 melanoma cell line transduced with shCont, shp16, shATR
Gene expression data in total mRNA from human SKMEL28 melanoma cell line transduced with shCont, shp16, shATR
PRJNA1233336 | ENA
GenomicsGene expression data in total mRNA from human SKMEL28 melanoma cell line shCont, shp16, shp16+shATR. Light and heavy polysome fractions for shCont and shp16.
Gene expression data in total mRNA from human SKMEL28 melanoma cell line shCont, shp16, shp16+shATR. Light and heavy polysome fractions for shCont and shp16.
PRJNA1019689 | ENA
TranscriptomicsEXP. 229_AC_RNAseq data of human cancer cell lines 94T778, SKBR3, AU565, SKMEL28 and A375 exposed to the selective MTOR inhibitor torkinib (PP242, Selleckchem, TX, USA) for 72 hours.
Drug concentrations were selected to halt cell cycle progression without affecting cell viability: 94T778 10 µM, A375, SKMEL28 and AU565 4 µM, SKBR3 0.8 µM. The pharmacologic inhibition of MTOR repressed expression of the homologous recombination (HR) and Fanconi Anemia (FA) pathways, and selectivel...
ORGANISM(S): Homo sapiens 
2020-04-09 | GSE148344 | GEO
GenomicsEXP. 229_AC_RNAseq data of human cancer cell lines 94T778, SKBR3, AU565, SKMEL28 and A375 exposed to the selective MTOR inhibitor torkinib (PP242, Selleckchem, TX, USA) for 72 hours.
EXP. 229_AC_RNAseq data of human cancer cell lines 94T778, SKBR3, AU565, SKMEL28 and A375 exposed to the selective MTOR inhibitor torkinib (PP242, Selleckchem, TX, USA) for 72 hours.
PRJNA623939 | ENA
TranscriptomicsMelanoma plasticity is regulated by mTOR-mediated crosstalk between MITF and TFE3
Bulk RNAseq was performed to identify differences in gene expression in SKMEL28 cells as related to MITF and TFE3 expression.
ORGANISM(S): Homo sapiens 
2025-03-20 | GSE273789 | GEO
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