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MetabolomicsSmall molecule produced by Photorhabdus interferes with ubiquinone biosynthesis in Gram-negative bacteria

We report identification of 3,6-dihydroxy-1,2-benzisoxazole (DHB) in a screen of Photorhabdus and Xenorhabdus, whose symbiotic relationship with eukaryotic nematodes favors secondary metabolites that meet several requirements matching those for clinically useful antibiotics. DHB is produced by Ph...

2024-09-06 | MTBLS10720 | MetaboLights
MetabolomicsThe phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functions. We have investigated in human neutrophils, the intricate...
2025-08-14 | MTBLS6215 | MetaboLights
MetabolomicsHypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239
Background: Elevated choline kinase alpha (ChoK) levels are observed in most solid tumors, including glioblastomas (GBM), and ChoK inhibitors have demonstrated limited efficacy in GBM models. Given that hypoxia is associated with resistance to GBM therapy, we hypothesized that tumor hypoxia c...
2024-06-18 | MTBLS6212 | MetaboLights
ProteomicsDiscovery of a small molecule inhibitor of the UBE2F-CRL5 axis that induces apoptosis and G2/M arrest and confers radiosensitization
Protein neddylation modification is catalyzed by a neddylation activating enzyme (NAE, E1), an E2 conjugating enzyme and an E3 ligase. In various types of human cancers, the neddylation pathway was abnormally activated. Our previous study validated that neddylation E2 UBE2F is a promising lung cance...
ORGANISM(S): Homo sapiens (Human) 
2022-10-19 | PXD036191 | Pride
Ube2f  neddylation  apoptosis  cell cycle arrest  small molecule inhibitor 
MetabolomicsPROMIS, global analysis of PROtein-Metabolite Interactions using Size separation in Arabidopsis thaliana
Small molecules not only represent cellular building blocks and metabolic intermediates, but also regulatory ligands and signaling molecules that interact with proteins. Although these interactions affect cellular metabolism, growth, and development, they have been largely understudied. Herein, we d...
2018-07-19 | MTBLS94 | MetaboLights
GenomicsCharacterization of a new small-molecule inhibitor of HDAC6 in glioblastoma
Characterization of a new small-molecule inhibitor of HDAC6 in glioblastoma
PRJNA601982 | ENA
TranscriptomicsTumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase
Deregulated expression of MYC is a driver of colorectal carcinogenesis, necessitating novel strategies to inhibit MYC function. The ubiquitin ligase HUWE1 (HECTH9, ARFBP1, MULE) associates with both MYC and the MYC-associated protein MIZ1. We show here that HUWE1 is required for growth of colorecta...
ORGANISM(S): Homo sapiens 
2014-10-21 | E-GEOD-59223 | biostudies-arrayexpress
GenomicsTrachea microbiome of chicken infected with Mycoplasma gallisepticum and treated with experimental small molecule growth inhibitor
Trachea microbiome of chicken infected with Mycoplasma gallisepticum and treated with experimental small molecule growth inhibitor Raw sequence reads
PRJNA766999 | ENA
GenomicsIdentification of covalent small-molecule inhibitors of STING
Identification of covalent small-molecule inhibitors of STING
PRJNA454500 | ENA
TranscriptomicsTranscriptional response of Escherichia coli O157 TUV93-0 to small molecule inhibitors of TTS
The transcriptional profile of Escherichia coli O157 treated with small molecule inhibitors of type III secretion was determined. Four variations of the small molecule inhibitor were assessed for global changes in transcription by treating cells with 20uM of inhibitor or an equivalent volume of DMSO...
ORGANISM(S): Escherichia coli 
2009-08-10 | E-GEOD-10319 | biostudies-arrayexpress
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