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ProteomicsUBE2F inhibits Natural Killer cell tumor immunity by activating the ARIH2-CRL5 complex to degrade interleukin 15 receptors
Interleukin-15 receptor (IL-15R) agonists induce anti-tumor immunity in pre-clinical models, however, dose-limiting toxicity has hampered their clinical development. An alternative is to target pathways downstream of the IL-15R to access different therapeutic profiles. We performed genome-wide CRISP...
ORGANISM(S): Homo sapiens (Human) 
2025-07-11 | PXD063595 | Pride
Human Natural killer cells Ube2f knockout 
TranscriptomicsE2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Ubiquitin and ubiquitin-like proteins (UBLs) are directed to targets by cascades of E1, E2, and E3 enzymes. The largest ubiquitin E3 subclass consists of cullin-RING ligases (CRLs), which contain one each of several cullins (CUL1, -2, -3, -4, or -5) and RING proteins (RBX1 or -2). CRLs are activated...
ORGANISM(S): Mus musculus 
2009-03-23 | E-GEOD-14088 | biostudies-arrayexpress
ProteomicsDiscovery of a small molecule inhibitor of the UBE2F-CRL5 axis that induces apoptosis and G2/M arrest and confers radiosensitization
Protein neddylation modification is catalyzed by a neddylation activating enzyme (NAE, E1), an E2 conjugating enzyme and an E3 ligase. In various types of human cancers, the neddylation pathway was abnormally activated. Our previous study validated that neddylation E2 UBE2F is a promising lung cance...
ORGANISM(S): Homo sapiens (Human) 
2022-10-19 | PXD036191 | Pride
Ube2f  neddylation  apoptosis  cell cycle arrest  small molecule inhibitor 
UnknownRHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis.
Not available
S-EPMC11832924 | biostudies-literature
GenomicsNeddylation E2 enzyme UBE2F promotes colitis and colon tumorigenesis by targeting the PTPRN-pSTAT5 axis
Neddylation E2 enzyme UBE2F promotes colitis and colon tumorigenesis by targeting the PTPRN-pSTAT5 axis
PRJNA1429294 | ENA
TranscriptomicsNeddylation E2 enzyme UBE2F promotes colitis and colon tumorigenesis by targeting the PTPRN-pSTAT5 axis
The inflammatory bowel diseases (IBDs) and colitis-associated colon cancers are common human diseases. Whether and how neddylation enzyme mechanistically regulates the process of these diseases are largely elusive. Here we report that UBE2F, a neddylation conjugation enzyme, plays a promoting role. ...
ORGANISM(S): Mus musculus 
2026-03-04 | GSE321690 | GEO
GenomicsUBE2F inhibits Natural Killer cell tumor immunity by activating the ARIH2-CRL5 complex to degrade interleukin 15 receptors
UBE2F inhibits Natural Killer cell tumor immunity by activating the ARIH2-CRL5 complex to degrade interleukin 15 receptors
PRJNA1259407 | ENA
UnknownNeddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage.
Not available
S-EPMC5315595 | biostudies-literature
UnknownInduction of NEDD8-conjugating enzyme E2 UBE2F by platinum protects lung cancer cells from apoptosis and confers to platinum-insensitivity.
Not available
S-EPMC7665193 | biostudies-literature
GenomicsTranscriptome data of Foxp3-Cre, Ube2m&Ube2f-deficient Treg cells from mice
Transcriptome data of Foxp3-Cre, Ube2m&Ube2f-deficient Treg cells from mice
PRJNA995532 | ENA
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