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MetabolomicsBrown-fat-mediated tumour suppression by cold-altered global metabolism

Glucose uptake is essential for cancer glycolysis and is involved in non-shivering thermogenesis of adipose tissues. Most cancers use glycolysis to harness energy for their infinite growth, invasion and metastasis. Activation of thermogenic metabolism in brown adipose tissue (BAT) by cold an...

2022-08-12 | MTBLS4856 | MetaboLights
ModelsLeon-Triana2021 - Competition between tumour cells and single-target CAR T-cells
This model of the use of chimeric antigen receptor (CAR)-T cell therapy in the treatment of solid tumours is described in the article: "Dual-Target CAR-Ts with On- and Off-Tumour Activity May Override Immune Suppression in Solid Cancers: A Mathematical Proof of Concept" Odelaisy León-Triana, Antonio...
2024-09-02 | BIOMD0000001013 | BioModels
Immuno-oncology 
ModelsLeon-Triana2021 - Competition between tumour cells and dual-target CAR T-cells
This model of the use of chimeric antigen receptor (CAR)-T cell therapy in the treatment of solid tumours is described in the article: "Dual-Target CAR-Ts with On- and Off-Tumour Activity May Override Immune Suppression in Solid Cancers: A Mathematical Proof of Concept" Odelaisy León-Triana, Antonio...
2024-09-02 | BIOMD0000001014 | BioModels
Immuno-oncology 
GenomicsThe profound effects of solid tumour-induced B cell dysregulation
The profound effects of solid tumour-induced B cell dysregulation
PRJNA923661 | ENA
GenomicsHysteresis of IL-10R primes solid tumour microenvironment for bacterial immunotherapy
Hysteresis of IL-10R primes solid tumour microenvironment for bacterial immunotherapy
PRJNA1095870 | ENA
ProteomicsGut microbiome-derived bacterial extracellular vesicles in patients with solid tumours
In this study, we performed a comparative analysis of gut microbiota composition and gut microbiome-derived bacterial extracellular vesicles (bEVs) isolated from patients with solid tumours and healthy controls. After isolating bEVs from the faeces of solid tumour patients and healthy controls, we p...
ORGANISM(S): Homo sapiens (Human) 
2024-08-08 | PXD047510 | Pride
Bacterial extracellular vesicles  gut microbiome  solid tumour  proteomics 
GenomicsPaired tumour biopsy gene expression data from patients with solid tumours, before and after combination treatment.
Paired tumour biopsy gene expression data from patients with solid tumours, before and after combination treatment.
PRJNA978115 | ENA
TranscriptomicsMicroRNA sequencing and Novel HPV miRNA discovery in HPV cell lines and human tissue samples
Human papillomaviruses (HPV) preferentially infect keratinocytes of mucous membranes or skin and cause numerous benign and malignant lesions at different anatomical locations. A number of DNA viruses encode their own miRNAs as well. To date, no studies have been able to validate viral miRNAs in papi...
ORGANISM(S): Homo sapiens 
2013-08-18 | E-GEOD-42380 | biostudies-arrayexpress
TranscriptomicsBreast Cancer Initiating Cells RNA-seq
We previously reported the isolation and in vitro propagation of highly tumorigenic mammospheres (MCFS) isolated from MCF7 breast cancer cell line. In this study we obtained gene expression profiles of MCFS and parental MCF7 cell lines using SOLiD RNA-sequencing after linear isothermal DNA amplifica...
ORGANISM(S): Homo sapiens 
2015-11-13 | E-MTAB-2811 | biostudies-arrayexpress
GenomicsExome sequencing of human ex vivo ovarian cancer models with matched stromal cells
Ascites or solid tumour from patients with ovarian cancer was collected and grown in culture as ex vivo models. Each sample has a mixture of tumour and stromal cells which were separated into individual cultures. Therefore each patient has tumour and stromal cultures originating from the same tissue...
ORGANISM(S): Homo sapiens 
2020-03-13 | E-MTAB-7225 | biostudies-arrayexpress
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